This trial has been completed.

Condition hodgkin's lymphoma
Treatment low dose ct
Sponsor University Health Network, Toronto
Collaborator Princess Margaret Hospital, Canada
Start date August 2010
End date September 2015
Trial size 31 participants
Trial identifier NCT01180010, UHN REB 08-0294-CE


This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner. Depending on the findings of the initial CT scan, we will then either repeat the scan in 1 year, or if indicated, send you for further scans or a biopsy. The information collected in this study will help researchers and clinicians in providing more concrete recommendations and screening guidelines for future survivors of Hodgkin's disease who have had similar exposures to radiation and/or chemotherapy and smoking.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case-only
Time perspective prospective

Primary Outcomes

Lung cancer detection rate using chest CT screening in patients at increased risk of lung cancer after Hodgkin's disease therapy.
time frame: 5 years
False-positive rates of using chest CT for lung cancer screening in this population.
time frame: 5 years

Secondary Outcomes

The stage distribution, clinical characteristics and pathologic features of the detected lung cancer
time frame: 5 years
The treatment and treatment outcome of lung cancer after Hodgkin's disease in a cohort of patients undergoing routine chest CT screening
time frame: 5 years

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: 1. 5 years or longer from initial Hodgkin's disease diagnosis 2. Current age 18 or older 3. Received mediastinal irradiation and/or alkylating-agent based chemotherapy 4. Smoking history of 10-pack years or more, or current smoker Exclusion Criteria: 1. Patients with a history of lung cancer 2. Patients currently receiving treatment for another cancer diagnosis (patients with another cancer, but currently disease-free and not receiving treatment are eligible) 3. Patients with known diagnosis of any metastatic cancer 4. Pregnant women. Female patients must: be at least one year post-menopausal, have had a hysterectomy, or have a serum pregnancy test to confirm that they are not pregnant. These measures must be taken in order to avoid doing a CT scan of a pregnant woman.

Additional Information

Official title Low-Dose Chest CT for Lung Cancer Screening in Survivors of Hodgkin's Disease
Principal investigator David Hodgson, MD
Trial information was received from ClinicalTrials.gov and was last updated in December 2016.
Information provided to ClinicalTrials.gov by University Health Network, Toronto.