Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes.
This trial is active, not recruiting.
|Conditions||metabolic diseases, neurological and mental health conditions|
|Sponsor||National University Hospital, Singapore|
|Collaborator||KK Women's and Children's Hospital|
|Start date||June 2009|
|End date||June 2020|
|Trial size||1247 participants|
|Trial identifier||NCT01174875, D/09/021, NMRC/TCR/004-NUS/2008|
This study aims to test the following two hypotheses in women recruited in early pregnancy and whose children will be followed up till at least 9 years of age.
- Epigenetic changes in conceptual tissues obtained at birth reflect the environment that the fetus was exposed to during development.
- The pattern of epigenetic marks in gene promoters obtained from DNA in birth tissues, together with genotype, phenotype, and environmental exposures, can be utilized to assess how the perinatal environment affects subsequent metabolic, neurodevelopmental and other phenotypes.
Pattern of epigenetic marks in birth tissues
time frame: Perinatal
Influence of prenatal and early postnatal factors
time frame: During pregnancy and infancy period
Female participants from 18 years up to 50 years old.
- Women 18 years and above
- Pregnant women attending the first visit (< 14 weeks GA) at the maternity units of KKH and NUH
- Singapore citizens or Singapore Permanent Residents
- Currently resident in mainland Singapore
- Intention to eventually deliver in KKH or NUH
- Intention to reside in Singapore for the next 5 years
- Intention to donate cord, cord blood and placenta
- The fetus should be racially homogenous with both sets of grandparents of the same ethnicity
- Women whose pregnancies end in miscarriages will be excluded
- Pregnant women on chemotherapy
- Exclude women with significant medical conditions e.g. Type 1 diabetes mellitus, psychosis etc.
- Exclude women on certain medications - e.g. psychotropic drugs.
- Mixed marriages will be excluded
|Official title||Growing Up in Singapore Towards Healthy Outcomes|
|Principal investigator||Yap-Seng Chong|
|Description||The dramatic emergence of non-communicable diseases (NCDs) in Asia has coincided with the rapid socioeconomic and nutritional transition taking place in the region, with the prevalence of diabetes rising five-fold in Singapore in less than four decades. One unique aspect of the epidemic has been the significant ethnic differences in predisposition among Asians and in the ethnic variation between BMI and the risk of developing insulin resistance. Apart from genetic factors, the differences in diet, lifestyle, cultural and religious practices might have altered the developmental programming through effects on the mechanisms of developmental plasticity. A center piece of this study is to examine how epigenetic change at birth both reflects past developmental influences and, in association with other factors, influences future trajectories of development and its relationship to NCDs. The longitudinal GUSTO birth cohort study allow us to examine associations between genomic variation and developmental-environmental interactions in the three distinct ethnic groups, Chinese, Malays and Indians, present in the Singaporean population.|
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