This trial is active, not recruiting.

Conditions aging, exercise, cardiovascular disease
Treatments exercise training, exercise cessation
Sponsor University of Maryland, Baltimore County
Collaborator Baltimore VA Medical Center
Start date July 2011
End date November 2014
Trial size 60 participants
Trial identifier NCT01169831, HP-00045413


Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Intervention model single group assignment
Masking open label
exercise training
2 weeks of daily aerobic exercise training
exercise cessation
Stopping all exercise for 2 weeks

Primary Outcomes

Baseline Endothelial progenitor cell number
time frame: Day 1
Final Endothelial Progenitor Cell Number
time frame: Day 15

Secondary Outcomes

Baseline Endothelial Reactivity
time frame: Day 1
Final Endothelial Reactivity
time frame: Day 15

Eligibility Criteria

Male or female participants from 50 years up to 80 years old.

Inclusion Criteria: - 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal Exclusion Criteria: - history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension

Additional Information

Official title Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Principal investigator Steven J Prior, Ph.D.
Trial information was received from ClinicalTrials.gov and was last updated in January 2016.
Information provided to ClinicalTrials.gov by Baltimore VA Medical Center.