This trial is active, not recruiting.

Condition glaucoma
Sponsor Indiana University
Start date February 2008
End date January 2020
Trial size 123 participants
Trial identifier NCT01145911, IGPS


To determine the relationships between ocular hemodynamics and glaucomatous optic neuropathy progression.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Glaucoma patients

Primary Outcomes

Ocular Blood Flow
time frame: various

Eligibility Criteria

Male or female participants at least 30 years old.

Inclusion Criteria: Patients will meet all of the following inclusion criteria to enter the study: 1. Age: 30 years or older. 2. Diagnosis: confirmed open-angle glaucoma in at least one eye: 1. glaucomatous visual field loss on Humphrey 24-2 or 10-2 perimetry 2. glaucomatous optic disc cupping 3. agreement between two baseline exams for reliability 3. Best corrected visual acuity at least 20/60 in at least one eye. 4. Prior Humphrey visual fields demonstrate acceptable reliability standards (see below). Exclusion Criteria: 1. Extensive Humphrey visual field damage consisting of either a mean deviation (MD) < -15 decibels or a clinically determined threat to fixation in both hemifields. 2. Evidence of exfoliation or pigment dispersion. 3. History of acute angle-closure or a narrow, occludable anterior chamber angle by gonioscopy. 4. History of chronic or recurrent inflammatory eye diseases (e.g., scleritis, uveitis). 5. History or signs of intraocular trauma. 6. Severe or potentially progressive retinal disease such as retinal degeneration, diabetic retinopathy, and retinal detachment. 7. Any abnormality preventing reliable applanation tonometry. 8. Current use of any ophthalmic or systemic steroid which may interfere with this investigation. 9. Cataract surgery within the past year. 10. Resting pulse < 50 beats per minute. 11. Severe, unstable or uncontrolled cardiovascular, renal, or pulmonary disease.

Additional Information

Official title The Study of Ocular Hemodynamics With Glaucoma Progression
Principal investigator Alon Harris, PhD
Description 1. To determine whether baseline ocular blood flow values are predictive of glaucomatous progression as determined by visual field analysis. 2. To determine how changes in ocular blood flow are related to visual field progression. 3. To determine how changes in ocular blood flow are related to changes in optic nerve structure and topographic change over time.
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by Indiana University.