This trial is active, not recruiting.

Condition cardiovascular disease
Treatment cheese
Sponsor University of Copenhagen
Collaborator The Danish Dairy Research Foundation, Denmark
Start date January 2010
End date June 2010
Trial size 60 participants
Trial identifier NCT01140165, A308


The aim of this study is to examine if a diet rich in cheese will have a beneficial effect on risk markers of cardiovascular disease compared to a diet rich in butter.

The primary parameters are total cholesterol as well as LDL-, HDL cholesterol and triacylglycerol (TAG). The secondary parameters are hsCRP, markers of insulin resistance, fasting insulin and glucose (HOMA). Furthermore bloodpressure is measured.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Intervention model crossover assignment
Masking open label
Primary purpose basic science
(Active Comparator)
Danish butter
cheese cheese, butter, dairy
the effect of cheese intake versus butter intake on blood lipids (primarily)
cheese cheese, butter, dairy
the effect of cheese intake versus butter intake on blood lipids (primarily)

Primary Outcomes

Total cholesterol
time frame: 6 weeks
LDL cholesterol
time frame: 6 weeks
HDL cholesterol
time frame: 6 weeks
time frame: 6 weeks

Secondary Outcomes

time frame: 6 weeks
time frame: 6 weeks
fasting hsCRP
time frame: 6 weeks
Blood pressure
time frame: 6 weeks

Eligibility Criteria

Male or female participants from 20 years up to 70 years old.

Inclusion Criteria: - Sign written consent - Age: 20-70 - BMI: 20-32 - Refrain from dietary supplements and blood donations prior to, and during the study Exclusion Criteria: - Known or suspected abuse of alcohol, drugs or medication - Poor compliance - Current or previously cardiovascular disease - Diabetes Mellitus or other severe chronic disease, including severe allergies

Additional Information

Official title Effects of Hard Cheese and Butter on Markers of Cardiovascular Disease -A Randomized Controlled Dietary Human Intervention
Principal investigator Tine Tholstrup, PhD
Trial information was received from ClinicalTrials.gov and was last updated in June 2010.
Information provided to ClinicalTrials.gov by University of Copenhagen.