This trial is active, not recruiting.

Conditions gastrointestinal neoplasm, gastric adenocarcinoma
Treatment irinotecan-capecitabine-oxaliplatin
Phase phase 2
Sponsor AHS Cancer Control Alberta
Collaborator Sanofi
Start date July 2010
End date January 2017
Trial size 47 participants
Trial identifier NCT01129310, IXOGoo1 25412


The investigators hypothesize IXO chemotherapy will have an improvement in response rate and acceptable toxicity for uncurable metastatic gastric cancer compared to historical controls.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment

Primary Outcomes

Overall Response Rate and dose limiting toxicity
time frame: 2 years

Secondary Outcomes

Progression Free Survival, overall survival, death, alterations in quality of life outcomes
time frame: 2 years

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - histologically documented gastric GEJ adenocarcinoma not previously treated with palliative systemic therapy. - Metastatic disease based on the presence of clinically and/or radiologically documented measurable disease based on RECIST. - ECOG performance status of 0,1 or 2. - Age ≥ 18 years - Life expectancy of least 3 months based on discretion of treating oncologist. - Adequate hematologic, hepatic, and renal function. - Patients who have received prior chemotherapy or radiation delivered as part of initial curative therapy (i.e. neoadjuvant or adjuvant chemotherapy administered alone and/or concurrently delivered with radiation and/or surgery) are permitted as long as that treatment was completed at least 6 months prior to study start date. - Patients may have received prior palliative radiotherapy (unless radiation was curative therapy to pelvis or to ≥25% of bone marrow stores) if this radiation was ≥ 4 weeks before study entry and patients must have recovered from the toxic effects of this treatment. - Patients may have received prior surgery if this surgery was ≥ 4 weeks before study entry and patients must have recovered from the toxic effects of this treatment. - Patients must have the ability to read, understand, and sign an informed consent and must be willing to comply with study treatment and follow-up. Exclusion Criteria: - Patients who have received palliative chemotherapy for their metastatic gastric or GEJ tumor. - Prior treatment with > 6 cycles of traditional alkylating agent-based chemotherapy, > 2 cycles of carboplatin-based chemotherapy, prior treatment with irinotecan or oxaliplatin chemotherapy, or concurrent treatment with other experimental drugs or anti-cancer therapy. - Curative radiation treatment to the pelvis or radiation therapy to ≥ 25% of bone marrow stores. - Lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome, short gut syndrome, or history of bowel obstruction due to peritoneal metastases. - Previous of concurrent malignancies, excluding curatively treated in situ carcinoma of the cervix or non-melanoma skin cancer, unless at least 5 years have elapsed since last treatment and the patient is considered cured. - Any serious medical condition within 6 months prior to study entry such as myocardial infarction, uncontrolled congestive heart failure,unstable angina, active cardiomyopathy, unstable ventricular arrhythmia, cerebrovascular diseases, uncontrolled hypertension, uncontrolled diabetes, uncontrolled psychiatric disorder, serious infection, active peptic ulcer disease, or other medical condition that ..... - Gilbert's disease - Known dihydropyrimidine dehydrogenase (DPD) deficiency. - Pre-existing neuropathy ≥ grade 2 from any cause. - Patients with unstable metastasis to the central nervous system are excluded. Patients who have treated brain metastasis and are off steroids, anticonvulsants, and have documented stability of lesions for at least 3 months may be eligible. A CT scan or MRI is NOT required to rule out brain metastases unless there is clinical suspicion of CNS involvement. - Pregnant of lactating women

Additional Information

Official title A Multicentre, Open-label Phase II Study of Irinotecan, Capecitabine(Xeloda), and Oxaliplatin (IXO) as First Line Treatment in Patients With Metastatic Gastric or Gastroesophageal (GEJ) Adenocarcinoma.
Description This is a single arm, open-label, multicentre, phase II trial in which patients with metastatic gastric or GEJ adenocarcinoma will be treated with the combination of irinotecan, capecitabine, and oxaliplatin (IXO).Patients will receive the combination of irinotecan, capecitabine, and oxaliplatin at the recommended phase II dose and sequence determined by the completed phase I trial. Patients will be treated on study until disease progression, overwhelming toxicity, or consent withdrawal.
Trial information was received from ClinicalTrials.gov and was last updated in January 2016.
Information provided to ClinicalTrials.gov by AHS Cancer Control Alberta.