Sugar-replacement Sweeteners, Taste Perception, and Blood Sugar Control
This trial is active, not recruiting.
|Sponsor||Washington University School of Medicine|
|Start date||May 2010|
|End date||April 2012|
|Trial size||17 participants|
|Trial identifier||NCT01128829, 09-0583/ 201102383|
Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study is to examine wether non caloric sweeteners affects how well the body works to control blood sugar. The study includes detailed blood sugar testing after drinking liquids that may contain sucralose. The investigators hypothesize that drinking liquids with sucralose will effect the amounts of specific appetite-affecting substances naturally produced by the body.
|Endpoint classification||pharmacodynamics study|
|Intervention model||single group assignment|
|Primary purpose||basic science|
The effect of sucralose on Glucagon Like Peptide -1 (GLP-1) release
time frame: Baseline
sucralose taste detection and GLP-1 (glucagon-like peptide - 1) levels
time frame: baseline
Male or female participants from 21 years up to 40 years old.
Inclusion Criteria: - body mass index (BMI) over 30. - Homeostasis model assessment of insulin resistance (HOMA-IR) < or = 2.6 Exclusion Criteria: - smoking or smoked within last six months - pregnant or breastfeeding - have malabsorptive syndromes - intestinal inflammatory disease - diabetes - liver or kidney disease - fructose intolerance - consuming more than one can of diet beverage or one spoonful of non-nutritive sweeteners (e.g. sucralose, aspartame, or saccharine) a week. - taking any medication that might affect metabolism or taste.
|Official title||Regulation of Incretin Release by Non-nutritive Sweeteners in Humans|
|Principal investigator||Marta Y Pepino de Gruev, Ph.D.|
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