This trial is active, not recruiting.

Conditions obesity, asthma
Sponsor Johns Hopkins University
Collaborator National Heart, Lung, and Blood Institute (NHLBI)
Start date September 2009
End date July 2012
Trial size 120 participants
Trial identifier NCT01127399, K23HL097081, NA_00027264


The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the defining features of asthma. This research is being done to determine how weight or body size affects airway size and airway smooth muscle (ASM) tone and function. The goal of the study will be to look at if and how, weight might affect lung functioning.

The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration (DI) response similar to what is seen in asthma.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective cross-sectional
Participants that will have had a bariatric surgery but do not have asthma.
Participants that will have had a bariatric surgery and have been physician diagnosed with asthma prior to the surgery.
Healthy participants that who will not be getting a bariatric surgery and who do not have asthma.
Healthy participants that will not be having a bariatric surgery but do have asthma.

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Age 18 years or older - BMI over 35 kg/m2 (Bariatric) or BMI between 25 and 28 kg/m2 (Control) - Physician diagnosis of asthma and on active asthma medication (if asthmatic) Exclusion Criteria: - Weight greater than 450 lbs - Unstable cardiovascular disease - Uncontrolled hypertension - Renal failure on dialysis - Cirrhosis - Pregnant or lactating - Bleeding disorders or Coumadin use - Recent hospitalization for asthma in the past 3 months - Active smoking or more than 10 pack year smoking history

Additional Information

Official title Effects of Obesity on Airway Caliber and Airway Smooth Muscle Tone
Principal investigator Emmanuelle Clerisme-Beaty, MD, MHS
Trial information was received from ClinicalTrials.gov and was last updated in June 2011.
Information provided to ClinicalTrials.gov by Johns Hopkins University.