Overview

This trial is active, not recruiting.

Conditions stage i breast cancer, stage ii breast cancer
Treatments cyclophosphamide, paclitaxel, trastuzumab
Phase phase 2
Target HER2
Sponsor University of Nebraska
Collaborator National Cancer Institute (NCI)
Start date March 2010
End date December 2014
Trial size 120 participants
Trial identifier NCT01106898, 371-09, NCI-2010-00608, P30CA036727

Summary

This phase II trial is studying the side effects and how well giving cyclophosphamide and paclitaxel with or without trastuzumab works in treating women with stage I or stage II breast cancer who have undergone surgery. Drugs used in chemotherapy, such as cyclophosphamide and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibody therapy, such as trastuzumab, with chemotherapy may kill more tumor cells. Giving these treatments after surgery may kill any tumor cells that remain after surgery

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
SYSTEMIC CHEMOTHERAPY: Patients receive cyclophosphamide IV over 1 hour and paclitaxel IV over 3 hours on day 1. Treatment repeats every 14 days for 6 courses in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY (Her-2 neu positive patients): Patients receive trastuzumab IV over 30 minutes on day 1. Treatment repeats every 14 days for 5 courses and then every 21 days for 14 courses in the absence of disease progression or unacceptable toxicity.
cyclophosphamide CPM
Given IV
paclitaxel Anzatax
Given IV
trastuzumab anti-c-erB-2
Given IV

Primary Outcomes

Measure
Primary toxicity (i.e., neutropenia)
time frame: Up to 7 years
Secondary toxicities (i.e., paclitaxel-related neuropathy, grade 3/4 cardiotoxicity and grade 3/4 nausea and vomiting)
time frame: Up to 7 years
Recurrence-free survival
time frame: Defined as the time from the start of treatment to recurrence, second malignancy, or death as a first event , assessed up to 2 years

Eligibility Criteria

Female participants at least 19 years old.

Inclusion Criteria: Histologically confirmed newly diagnosed Stage I-II breast cancer Women of reproductive potential must be non-pregnant and non-nursing and must agree to employ an effective barrier method of birth control throughout the study and for up to 6 months following treatment Women of child-bearing potential must have a negative pregnancy test within 7 days of initiating study Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Absolute neutrophil count greater than or equal to 1,500/mcl Platelet count equal to or greater than 150,000/mcl Hemoglobin > 11gm/dl Alkaline phosphatase equal or less than 1.5 times the upper limit of normal (ULN) Total bilirubin equal to or less than 1.5 times the ULN Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) no greater than 1.5 times the ULN Creatinine less than 1.5 times the ULN Able to give informed consent All included patients must have normal cardiac function as defined by an ejection fraction of > 50% by echocardiogram Able to return for treatment and follow-up on the specified days Exclusion Criteria: Prior malignancy; except for adequately treated basal cell or squamous cell skin cancer or noninvasive carcinomas Patients with pre existing Grade II peripheral neuropathy Patients with prior chemotherapy Stage IV or metastatic breast cancer Pregnant or nursing women Inability to cooperate with treatment protocol No active serious infections or other conditions precluding chemotherapy Any comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this protocol (e.g. unstable angina, myocardial infarction within 6 months, severe infection, etc.) Known hypersensitivity to any component of required drugs in the study Known positive for human immunodeficiency virus (HIV) or infectious hepatitis, type A, B or C or active hepatitis Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities (Prior to study entry, any electrocardiograph [ECG] abnormality at screening has to be documented by the investigator as not medically relevant)

Additional Information

Official title A Phase II Study of Adjuvant Therapy Using a Regimen of Cyclophosphamide, Paclitaxel With or Without Trastuzumab in Stage I-II Breast Cancer Patients
Principal investigator Elizabeth Reed
Description OBJECTIVES: I. To determine the toxicities and ability to complete the planned treatment of a dose-dense regimen of cyclophosphamide and paclitaxel with or without trastuzumab in patients with newly diagnosed stage I-II breast cancer. II. To estimate recurrence free survival of a dose-dense regimen of cyclophosphamide and paclitaxel with or without trastuzumab in patients with newly diagnosed stage I-II breast cancer. OUTLINE: SYSTEMIC CHEMOTHERAPY: Patients receive cyclophosphamide intravenously (IV) over 1 hour and paclitaxel IV over 3 hours on day 1. Treatment repeats every 14 days for 6 courses in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY (Her-2 neu positive patients): Patients receive trastuzumab IV over 30 minutes on day 1. Treatment repeats every 14 days for 5 courses and then every 21 days for 14 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up periodically for 3 years.
Trial information was received from ClinicalTrials.gov and was last updated in May 2013.
Information provided to ClinicalTrials.gov by University of Nebraska.
Location data was received from the National Cancer Institute and was last updated in May 2016.