Continuous Venovenous Hemofiltration Versus Continuous Venovenuous Hemodialysis
This trial is active, not recruiting.
|Condition||acute renal failure|
|Treatments||continuous venovenous hemofiltration (cvvh), continuous venovenous hemodialysis (cvvhd)|
|Sponsor||University of Chicago|
|Start date||January 2009|
|End date||September 2015|
|Trial size||20 participants|
|Trial identifier||NCT01062984, IRB# 15947A|
Acute kidney injury is often treated with the use of continuous renal replacement therapy. Two commonly used treatments are continuous venvenous hemofiltration (CVVH)and continuous venovenous hemodialysis (CVVHD). CVVH uses convective clearance to remove toxins and solutes from the patients circulation, while CVVHD relies on diffusive clearance to remove these same toxins/solutes. This study will evaluate which of these two methods is more effective at clearing the body of waste/solutes.
We hypothesize that renal replacement therapy by either modality (hemodialysis or hemofiltration; CVVHD or CVVH, respectively) using a modern membrane and higher blood flow rates will be associated with similar clearances of both small and middle molecular weight solutes. We further believe that continuous renal replacement therapy using CVVHD will be associated with decreased clotting events and longer hemofilter survival, as well as improved resource utilization (i.e. nursing time, alarms, etc.).
|Intervention model||parallel assignment|
To compare the clearance of urea and creatinine by RRT using continuous venovenous hemofiltration versus continuous venovenous hemodialysis.
time frame: 48 hours
To compare the clearance cystatin C and inflammatory cytokines (IL-6 and IL-10) by RRT using continuous venovenous hemofiltration versus continuous venovenous hemodialysis.
time frame: 48 hours
Male or female participants at least 18 years old.
Inclusion Criteria: - Age 18 or older and able to sign consent (or surrogate). - Must have been referred to the inpatient Nephrology consult service for evaluation of AKI. - Expected survival of at least 48 hours. Exclusion Criteria: - Hemoglobin < 8 g/dl - Serum potassium ≥6.5mEq/L - Weight > 120kg.
|Official title||A Comparison of the Efficacy of Continuous Venovenous Hemofiltration Versus Continuous Venovenous Hemodialysis for Renal Replacement Therapy in Acute Kidney Injury|
|Principal investigator||Jay Koyner, MD|
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