Overview

This trial is active, not recruiting.

Condition chiari type i malformation
Sponsor Duke University
Start date June 2009
End date August 2020
Trial size 2000 participants
Trial identifier NCT01060800, Pro00011231

Summary

Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S). Our research is aimed at learning if CM1/S is indeed caused by factors inherited through the family and, if so, which genes are involved.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model family-based
Time perspective cross-sectional

Primary Outcomes

Measure
Genetic factors contributing to Chiari Type I malformation
time frame: end of study

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Families who have TWO OR MORE family members with Chiari Type I Malformation, with or without syringomyelia. These family members must be related to each other by blood, and BOTH must be willing to participate. Exclusion Criteria: - Singleton cases of Chiari Type I Malformation - Presence of supratentorial or infratentorial tumors - Presence of a lumbar shunt - History of birth trauma - History of spina bifida - History of cervical or cranial surgery unrelated to CM1

Additional Information

Official title The Genetics of Chiari Type I Malformation (CMI) With or Without Syringomyelia
Principal investigator Allison Ashley-Koch, PhD
Description Duke University Medical Center is actively recruiting families who have TWO OR MORE family members with Chiari Type I Malformations, with or without syringomyelia. These family members must be related to each other by blood, and BOTH must be willing to participate.
Trial information was received from ClinicalTrials.gov and was last updated in June 2016.
Information provided to ClinicalTrials.gov by Duke University.