This trial is active, not recruiting.

Conditions exercise training, cognitive function
Sponsor Medical University of Vienna
Collaborator National Bank of Austria
Start date December 2008
End date February 2014
Trial size 136 participants
Trial identifier NCT01045031, Grant Project number 12979


There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly. To the investigators knowledge no studies have evaluated the effects of extensive endurance exercise training on cognitive functions by studying elderly marathon runners and bicyclists. On the basis of the scientific literature published so far it is not known whether the beneficial impact of endurance exercise training depends on the intensity of training.

The investigators therefore designed a cohort study with adequate power in order to evaluate the effects of intensive endurance exercise training on cognition. This trial, an Austrian prospective cohort study in cognitive function of elderly marathon-runners (APSOEM) is being conducted and will compare neuropsychological performance outcomes of elderly marathon runners or bicyclists with controls matched concerning age, education years, occupation, and verbal intelligence.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective

Primary Outcomes

the proportion of subjects, who will develop mild cognitive impairment
time frame: 5 years
impairment in the neurocognitive performance scores
time frame: 5 years

Secondary Outcomes

brain-derived neurotrophic factor (BDNF)
time frame: 5 years
Apo e4 carrier state
time frame: 5 years
self rating by questionnaires
time frame: 5 years
insulin-like growth factor (IGF-1)
time frame: 5 years

Eligibility Criteria

Male or female participants at least 60 years old.

Inclusion Criteria: - Current Marathon runners or marathon bicyclists and controls from the greater Vienna area Exclusion Criteria: - Current of past neurotoxic exposure - Not German as native language - Diseases, that might affect central nervous system (stroke, meningitis, meningeoma, hydrocephalus,..) - Manifest cardiovascular disease - Alcoholism

Additional Information

Official title Austrian Prospective Cohort Study in Cognitive Function of Elderly Marathon-runners
Trial information was received from ClinicalTrials.gov and was last updated in January 2014.
Information provided to ClinicalTrials.gov by Medical University of Vienna.