Measured Hypocretin Levels and Recovery After Hip Surgery
This trial is active, not recruiting.
|Start date||July 2009|
|End date||December 2013|
|Trial size||50 participants|
|Trial identifier||NCT01009710, 16339, SU-07162009-3301|
A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
Anesthetic Recovery Times
time frame: 0-72 hours after surgery
sensitivity to sevoflurane during inhalation induction to anesthesia, determined by bispectral index of the EEG
time frame: during anesthetic induction
pain and sleepiness
time frame: from 0-72 hours after surgery
Male or female participants at least 18 years old.
Inclusion Criteria:- Adult (18 years of age or older) - Male or female - Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic. - Comprehend spoken and written English Exclusion Criteria:- ASA physical status > III (patients with severe systemic disease) - Diagnosed psychiatric disease (except mild depression) - Any diagnoses CNS disease or dementia - History of stroke - History of untreated thyroid disease - Difficulty in airway management (ventilation and/or intubation) - Body Mass Index (BMI) > 35 kg/m2
|Official title||Preoperative Cerebrospinal Fluid (CSF) Levels of Hypocretin and Recovery After Hip Surgery With Combined Spinal and General Anesthesia|
|Principal investigator||Anthony Doufas|
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