This trial is active, not recruiting.

Conditions exercise capacity, physical activity, hypertension, overweight and obesity, metabolic syndrome
Sponsor Oslo University Hospital
Collaborator Norwegian Red Cross
Start date June 2007
End date June 2010
Trial size 60 participants
Trial identifier NCT01008306, S-07245b


Renal transplantation of children started in Norway in 1970.Since the beginning, >80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.

Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective cross-sectional
Renal transplanted children and adolescents (2-18yrs) transplanted between 1993-2006. Renal transplanted young adults aged 20-35 yrs old, transplanted from 1983 onwards.

Secondary Outcomes

other cardiovascular risk factors
time frame: 2007-2010
time frame: 2007-2010
impaired glucose intolerance
time frame: 2007-2010
left ventricular hypertrophy,
time frame: 2007-2010

Eligibility Criteria

Male or female participants from 2 years up to 38 years old.

Inclusion Criteria: - Transplanted after 1983, functioning graft Exclusion Criteria: - Patients in dialysis - In part of the study concerning treadmill testing: Age<8 years, orthopedic limitations

Additional Information

Official title Outcome After Pediatric Renal Transplantation: Cardiorespiratory Fitness, Cardiovascular Risk Factors and Quality of Life
Trial information was received from ClinicalTrials.gov and was last updated in November 2009.
Information provided to ClinicalTrials.gov by Oslo University Hospital.