Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
This trial is active, not recruiting.
|Condition||postural tachycardia syndrome|
|Start date||October 2009|
|End date||June 2017|
|Trial size||40 participants|
|Trial identifier||NCT01000350, 090942|
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
Difference in VO2max between saline day and placebo day
time frame: Within 2 week
Exercise capacity/Maximal Load (Watts) during peak VO2
time frame: Less than 2 weeks
Cardiac output between exercise tests (inert gas rebreathing technique)
time frame: 2-10 Days between exercise tests
Male or female participants from 18 years up to 65 years old.
Inclusion Criteria: - Meet diagnostic criteria of Postural Tachycardia Syndrome (POTS) 28 - Age between 18-65 years - Male and female are eligible (although the majority of POTS patients are female). - Able and willing to provide informed consent Exclusion Criteria: - Presence of medical conditions that can explain postural tachycardia (e.g., acute dehydration, medications) - Pregnancy - Other factors which in the investigator's opinion would prevent the subject from completing the protocol. - Patients who are bedridden or chair-ridden
|Official title||Intravenous Saline on Exercise Tolerance in Orthostatic Intolerance|
|Principal investigator||Satish R Raj, MD MSCI|
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