Overview

This trial is active, not recruiting.

Condition healthy
Treatments fast and exercise, exercise
Sponsor University of Aarhus
Start date September 2009
End date June 2012
Trial size 8 participants
Trial identifier NCT00978640, 07.09.2009

Summary

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model crossover assignment
Masking open label
Primary purpose basic science
Arm
(Experimental)
36 h fast and 1 h ergometer cycling 50% VO2max
fast and exercise
fasting 36 h and exercise 1 h 50% VO2max
(Experimental)
1 h ergometer cycling 50% VO2max
exercise
exercise 1 h 50% VO2max

Primary Outcomes

Measure
Sirt1 activity
time frame: 60 min

Secondary Outcomes

Measure
secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
time frame: 4 h

Eligibility Criteria

Male participants from 18 years up to 45 years old.

Inclusion Criteria: - healthy men - Body mass index (BMI) 20-26 - age 18-45 years Exclusion Criteria: - any kind of disease - any use of medicine

Additional Information

Official title Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise
Trial information was received from ClinicalTrials.gov and was last updated in June 2012.
Information provided to ClinicalTrials.gov by University of Aarhus.