Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise
This trial is active, not recruiting.
|Treatments||fast and exercise, exercise|
|Sponsor||University of Aarhus|
|Start date||September 2009|
|End date||June 2012|
|Trial size||8 participants|
|Trial identifier||NCT00978640, 07.09.2009|
Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).
Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.
In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
|Primary purpose||basic science|
36 h fast and 1 h ergometer cycling 50% VO2max
1 h ergometer cycling 50% VO2max
time frame: 60 min
secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
time frame: 4 h
Male participants from 18 years up to 45 years old.
Inclusion Criteria: - healthy men - Body mass index (BMI) 20-26 - age 18-45 years Exclusion Criteria: - any kind of disease - any use of medicine
|Official title||Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise|
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