This trial is active, not recruiting.

Condition down syndrome
Phase phase 2
Sponsor University of Sao Paulo
Collaborator Conselho Nacional de Desenvolvimento Científico e Tecnológico
Start date August 2007
End date April 2009
Trial size 60 participants
Trial identifier NCT00952354, 473492/2007-5, CNPq-473492/2007-5


The objective of this research is to verify the language of children with Down syndrome concerning lexical, syntactic and semantic aspects using MLU. The hypothesis is that children with Down syndrome will present low performance, regarding not only the quantitative measures as MLU-m, MLU-w, GM-1 and GM-2, but also regarding the qualitative aspects of their production, when compared to children with typical development.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective cross-sectional
60 children aged from 3 to 10 years, both genders, observed in a symbolic play situation with their language therapists

Eligibility Criteria

Male or female participants from 3 years up to 10 years old.

Inclusion Criteria: - genetic diagnosis of Down syndrome - good health conditions - normal results on audiologic evaluation - pediatric and ear, nose and throat periodic check ups. - attend speech-language therapy at the Speech Language Pathology Laboratory in Syndromes and Sensorimotor Deficits (SLPL-SSD) of the School of Medicine of the University of São Paulo. Exclusion Criteria: - submission to long term hospitalizations due to heart diseases and major respiratory airway infections, that may interfere in the child's global development - presence of visual or auditory important deficits

Additional Information

Official title Oral Language in Children With Down Syndrome: Lexical, Syntactic and Semantic Aspects
Principal investigator Rosangela V Andrade, PhD
Description One of the alternatives to observe and assess language development and language disorders is to analyze spontaneous language samples, which allos the identification of qualitative and quantitative aspects. The analysis involves the MLU-morphemes, MLU-words and words classes. All words produced are analyzed, including interjections, adverbs and adjectives.Word classes with grammatical characteristics present lower averages, as prepositions and conjunctions. Reference parameters are the ones of the spoken language. The objective assessment with qualitative and quantitative data may help the speech and language pathologist/therapist to determine therapeutic guidelines to each patient.
Trial information was received from ClinicalTrials.gov and was last updated in August 2009.
Information provided to ClinicalTrials.gov by University of Sao Paulo.