Overview

This trial is active, not recruiting.

Conditions colorectal cancer, nasopharyngeal cancer
Treatment tumor biopsies
Sponsor National University Hospital, Singapore
Start date July 2008
End date December 2014
Trial size 500 participants
Trial identifier NCT00943891, MC01/09/08

Summary

1. To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens

2. To determine the association between VEGF-C,-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma

3. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer. Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma, the investigators intend to analyze archived specimens collected in a previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD, LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques. Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case-crossover
Time perspective cross-sectional
Arm
tumor biopsies

Eligibility Criteria

Male or female participants at least 21 years old.

Inclusion Criteria: - Male and female patients are eligible - Patients 21 years or older Exclusion Criteria: - None

Additional Information

Official title A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
Principal investigator Ross Andrew Soo, MBBS
Trial information was received from ClinicalTrials.gov and was last updated in January 2014.
Information provided to ClinicalTrials.gov by National University Hospital, Singapore.