This trial is active, not recruiting.

Condition breast cancer
Treatment cone beam ct
Sponsor University Health Network, Toronto
Collaborator Princess Margaret Hospital, Canada
Start date June 2009
End date April 2016
Trial size 160 participants
Trial identifier NCT00923871, UHN REB 09-0197-CE


Breast radiation treatment is planned from a Computed Tomography (CT) scan. This study is designed to investigate a method to reduce the time between the planning of radiation treatment and its actual start by automating the intensity-modulated radiation therapy (IMRT) planning process. The investigators plan to examine data from another scan called Cone Beam Computed Tomography (CBCT). A CBCT scan provides similar information to a conventional CT scan, however the images for CBCT are acquired at the treatment unit (linear accelerator used for treatment). Using these x-ray pictures of patients, the study team consisting of a radiation oncologist, a medical physicist and a radiation therapist will create a custom treatment plan unique to each patient. By doing this, the investigators hope to reduce the amount of time spent waiting for treatment and the number of hospital visits for patients in the future.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
cone beam ct
Patients will also have a CBCT scan when they are having their first IMRT treatment.

Primary Outcomes

To generate on-line IMRT treatment plans using automated tools based on CBCT images acquired at the treatment unit.
time frame: 3 years

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: - Patients with breast cancer who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions. - Patients with any stage of breast cancer. - Patients with prior treatment such as surgery or chemotherapy for any type of cancer. - Able to provide a written informed consent. - 18 years of age or older. Exclusion Criteria: - < 18 years of age. - Unable to provide informed consent. - Males. - Patients who received partial breast radiation and not the standard dose. - Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions.

Additional Information

Official title Automating the Breast Radiation Therapy Process to Improve Efficiency
Principal investigator Robert Dinniwell, MD
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by University Health Network, Toronto.