Fludeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) Cervical Heterogenity Imaging Study
This trial is active, not recruiting.
|Treatment||positron emission tomography|
|Sponsor||Washington University School of Medicine|
|Start date||August 2008|
|End date||November 2010|
|Trial size||25 participants|
|Trial identifier||NCT00907140, 08-0804|
Rationale: Diagnostic procedures, such as positron emission tomography (PET) using fluorodeoxyglucose (FDG), may help determine response to standard cancer therapy in patients with cervical cancer
The purpose of this study is to evaluate the change in cervical tumor heterogenity as measured by FDG-PET/CT imaging.
|Intervention model||single group assignment|
The overall goal of this pilot study is to evaluate the change in cervical tumor FDG heterogeneity and SUVmax during chemoradiation.
time frame: FDG PET/CT imaging is performed at: Baseline, 2 & 4 weeks of therapy, and 3 months after completing therapy
To correlate changed in FDG heterogeneity and SUVmax with response to therapy.
time frame: 5 years
Female participants at least 18 years old.
Inclusion Criteria: 1. Biopsy-proven cervical cancer. (FIGO stage-Ib2-IVa) 2. Age ≥ 18 3. Able to receive chemoradiation therapy with Cisplatin. 4. Non-pregnant status in women of childbearing potential. 5. No other active cancer at the time of diagnosis of cervical cancer Patients cannot have received treatment for any malignancy, with the exception of non-melanoma skin cancer, in the past 5 years. 6. Patients with distant metastatic disease are eligible provided the estimated survival of the patient is at least 1 year. 7. Scheduled to undergo or have already undergone FDG-PET/CT imaging for clinical staging of cervical cancer at Barnes-Jewish Hospital Clinical PET Facility on a Biograph 40 PET/CT scanner 8. Able to give informed consent Exclusion Criteria: 1. Age < 18 2. Patients with a known active malignancy other than cervical carcinoma. 3. Pregnant and breastfeeding patients. 4. Subjects whose tumors are not FDG avid on baseline standard of care FDG-PET/CT imaging
|Official title||Assessment of Changes in Pattern and Magnitude of Tumor FDG Uptake During Chemoradiation as a Predictor of Response to Concurrent Radiation Therapy and Chemotherapy in Patients With Cervical Cancer|
|Principal investigator||Perry W Grigsby, M.D.|
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