This trial is active, not recruiting.

Condition primary open angle glaucoma (poag)
Treatments perimetry, confocal scanning laser tomography, optical coherence tomography (oct)
Sponsor University Hospital Tuebingen
Collaborator Alcon Research
Start date April 2010
End date June 2015
Trial size 12 participants
Trial identifier NCT00902109, SCOPE-G-BETA


The purpose of this study is to compare the two psychophysical perimetric techniques regarding progression of the visual field.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
perimetry, HRT, OCT
perimetry Humphrey Field Analyzer 745i (HFA), Interzeag Octopus 101
different perimetric devices, different perimetric grids: Octopus: New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) HFA: 30-2, Sita (Swedish Interactive Thresholding Algorithm) full threshold
confocal scanning laser tomography Heidelberg Retina Tomograph (HRT)
HRT examinations for the clinical evaluation of the optic disc.
optical coherence tomography (oct) Spectralis-OCT (Heidelberg Engineering, Heidelberg, Germany)
imaging of the retinal nerve fiber layer

Primary Outcomes

Comparison of rate of progression
time frame: 36 month

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - primary open angle glaucoma (POAG) - spherical ametropia max. ± 8 dpt - cylindrical ametropia max. ± 3 dpt - distant visual acuity > 10/20 - pupil diameter > 3 mm Exclusion Criteria: - diabetic retinopathy - asthma - history of epilepsy or significant psychiatric disease - medications known to effect visual field sensitivity - infections (e.g., keratitis, conjunctivitis, uveitis) - severe dry eyes - miotic drug - squint - nystagmus - albinism - any ocular pathology, in either eye, that may interfere with the ability to obtain visual fields - keratoconus - intraocular surgery (except for uncomplicated cataract surgery) performed < 3 month prior to screening - history or signs of any visual pathway affection other than glaucoma - history or presence of macular disease and/or macular edema, ocular trauma, medications known to affect visual field sensitivity

Additional Information

Official title Pilot Study to Compare the Humphrey Field Analyzer (HFA) 30-2 Swedish Interactive Threshold Algorithm (SITA) Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE), Using a New Fast GATE (German Adaptive Threshold Estimation) in Glaucoma Patients Under Topic Therapy
Principal investigator Ulrich Schiefer, Prof. Dr. med.
Trial information was received from ClinicalTrials.gov and was last updated in May 2014.
Information provided to ClinicalTrials.gov by University Hospital Tuebingen.