This trial is active, not recruiting.

Condition hyperventilation
Treatments breathing re-training, breathing re-training and musculoskeletal techniques
Phase phase 3
Sponsor Royal Brompton & Harefield NHS Foundation Trust
Start date July 2007
End date July 2009
Trial size 60 participants
Trial identifier NCT00895219, 06/Q0404/64


Traditionally, the physiotherapy management of people with dysfunctional breathing or hyperventilation syndrome is breathing re-training. There is increasing clinical evidence that structural and functional changes develop in the muscles and connective tissues of the chest wall, abdomen and back when the upper chest accessory pattern of breathing is used over time. When treatment includes breathing techniques only it is difficult for a person with chronic hyperventilation, who has developed muscle and connective tissue changes, to revert to using the normal lower chest diaphragmatic breathing pattern. In clinical practice when the problems which have developed in the musculoskeletal system are addressed, the patient reverts more quickly to the lower chest pattern of breathing but there is as yet little evidence to support this clinical finding.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking single blind (outcomes assessor)
Primary purpose treatment
(Active Comparator)
Breathing re-training
breathing re-training
Breathing re-training
(Active Comparator)
Breathing re-training and musculoskeletal physiotherapy techniques
breathing re-training and musculoskeletal techniques
Breathing re-training and musculoskeletal physiotherapy techniques including mobilisation techniques to normalise muscle and joint restrictions, doming of the diaphragm to enhance contraction and relaxation, and rib raising to free restriction in rib cage motion.

Primary Outcomes

Nijmegen Questionnaire
time frame: 0, 2, 4, 8, 12 and 26 weeks

Secondary Outcomes

Six-minute walking test
time frame: 0, 2, 4, 8, 12 & 26 weeks

Eligibility Criteria

Male or female participants at least 16 years old.

Inclusion Criteria: - diagnosis of dysfunctional breathing (Nijmegen score of more than 23) Exclusion Criteria: - active metastatic disease - osteoporotic disease - dysfunctional breathing as a consequence of respiratory or cardiac disease

Additional Information

Official title A Comparison of the Effects of Respiratory Physiotherapy Alone and Respiratory Physiotherapy Combined With Musculoskeletal Techniques in the Management of Dysfunctional Breathing
Trial information was received from ClinicalTrials.gov and was last updated in May 2009.
Information provided to ClinicalTrials.gov by Royal Brompton & Harefield NHS Foundation Trust.