This trial is active, not recruiting.

Conditions breast cancer, dermatitis
Treatments sulforaphane-containing broccoli sprout extracts (active agent), vehicle (inactive control)
Phase phase 2
Sponsor Sidney Kimmel Comprehensive Cancer Center
Start date April 2009
End date November 2012
Trial size 32 participants
Trial identifier NCT00894712, J-0838, NA_00018779


The investigators plan to investigate the protective effects of topical sulforaphane-containing broccoli-sprout extracts (BSE) on radiation-induced dermatitis in women undergoing external-beam radiation therapy for breast cancer. Topical sulforaphane induces phase 2 enzymes that are protective against oxidants, electrophiles, and inflammation (Talalay and Fahey, 2001) - all of which are generated by both ultraviolet and ionizing radiation. Previous work from the investigators' group demonstrated that sulforaphane treatment protects against ultraviolet radiation-induced erythema of human skin (IRB protocol NA_00004897; Talalay et al. 2007). This investigation will extend the investigators' previous work by employing ionizing rather than ultraviolet radiation.

The investigators propose a two part sequential protocol (Study A and Study B). Both studies will involve women with breast cancer who have undergone lumpectomy and are scheduled for adjuvant external beam radiation treatment. In study A, the investigators will validate their technique for measurement of skin erythema using a device called a chromometer; no active agent will be applied (up to 6 women). Study B will follow completion of Study A. Study B will involve the application of broccoli sprout extracts (BSE) or vehicle alone to determine if sulforaphane can reduce radiation-induced erythema (27 women). Four adjacent, 1.5-cm diameter areas-of-interest on the affected breast will be located by means of an adhesive vinyl template which can be accurately and repeatedly placed at the same position. Two of the four areas will be treated with BSE (active agent) and two with vehicle (inactive control). BSE will be applied on three days weekly throughout the 5-week period of whole breast radiation. Erythema will be noninvasively quantified by measuring the red-reflectance of the skin with a chromometer up to three times weekly throughout treatment. A total of 33 patients are to be enrolled.

The investigators' objective is to determine and quantify the effect of topical BSE on radiation-induced skin erythema. This study will employ standard, clinically-accepted radiation doses and techniques that are safe and well tolerated. The safety and tolerability of both oral and topical broccoli sprout preparations is well established; no safety concerns have been noted. (Shapiro et al. 2006; Dinkova-Kostova et al. 2007).

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective

Primary Outcomes

Variance of the skin erythema measurements due to non-radiation effects.
time frame: Week 0 and Week 1 of radiation treatment
Absolute change in red reflectance of the skin.
time frame: before and after radiation

Secondary Outcomes

Clinical grade of dermatitis (per NCI CTCAE v3.0 guidelines) for each region.
time frame: weekly

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: - Must have pathologically confirmed invasive adenocarcinoma or ductal carcinoma in situ of the breast. - Patients must have undergone segmental mastectomy (i.e., lumpectomy). - Patients must not have received prior radiation therapy to the breast. - Patients must not have active local-regional disease prior to registration. - Patients must not be pregnant because of the potential for fetal harm as a result of radiation treatment. Women of child-bearing age will be given a serum pregnancy test prior to study entry to ensure they are not pregnant. They will also be counseled on the importance of avoiding pregnancy and hormonal contraception while undergoing radiation therapy. - Patients must not have a serious medical or psychiatric illness which prevents informed consent or compliance with treatment. - All patients must be informed of the investigational nature of this study and give written informed consent in accordance with institutional and federal guidelines. Exclusion Criteria: - Visible skin pathology, excessive freckles, or skin blemishes in the test area. - History of skin disease or hypersensitivity and repeated contact allergies. - Sarcoma or squamous cell histology. - Metastatic disease to the breast. - Current tobacco use.

Additional Information

Official title Effect of Topical Application of Sulforaphane- Containing Broccoli Sprout Extracts on Radiation Dermatitis During External-beam Radiation Therapy for Breast Cancer
Principal investigator Richard Zellars, M.D.
Trial information was received from ClinicalTrials.gov and was last updated in October 2014.
Information provided to ClinicalTrials.gov by Sidney Kimmel Comprehensive Cancer Center.