Overview

This trial is active, not recruiting.

Condition chronic obstructive pulmonary disease
Sponsor Johns Hopkins University
Collaborator National Heart, Lung, and Blood Institute (NHLBI)
Start date January 2008
End date July 2013
Trial size 200 participants
Trial identifier NCT00889447, NA_00013323

Summary

This research is being done to study mechanisms of progression of COPD and to develop treatments for it. The investigators are doing the present study to identify people age 40 and older with mild to moderate COPD who will qualify for such studies to include in a database. The study will include establishing a screening evaluation or characterization of the following two studies:

- Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980

- Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case-only
Time perspective cross-sectional

Eligibility Criteria

Male or female participants at least 40 years old.

Inclusion Criteria: - Age 40 years and older, either sex - Mild to moderate COPD (FEV1/FVC ratio ≤ 0.70, FEV1 30-70% predicted, DLCO ≥35% predicted) - On stable maintenance therapy for 2 months - Current or former smoker (patient report of at least a 10 pack-year history) - Ability to understand and willingness to sign consent documents Exclusion Criteria: - COPD exacerbation requiring treatment within past 6 weeks - Untreated arterial hypertension (systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg) - Decompensated heart failure - Myocardial infarction within past 3 months or ever - Evidence of interstitial, occupational or chronic infectious lung disease - Renal dysfunction - Supplemental oxygen > 2L/m at rest - Failure to keep screening appointments

Additional Information

Official title Screening Evaluation for Studies of COPD
Principal investigator Gregory Diette, MD,MHS
Description This is a program to recruit and screen participants for clinical trials or more detailed observational studies of COPD. There are no interventions or comparative results to be published from this study.
Trial information was received from ClinicalTrials.gov and was last updated in April 2013.
Information provided to ClinicalTrials.gov by Johns Hopkins University.