Overview

This trial is active, not recruiting.

Conditions fabry disease, left ventricular hypertrophy
Sponsor Medical University of Vienna
Collaborator Medical University of Graz
Start date January 2009
End date January 2012
Trial size 4000 participants
Trial identifier NCT00871611, VIE190109

Summary

The prevalence of Anderson - Fabry disease in patients with left ventricular hypertrophy is unclear. The investigators will examine urine - α - Galactosidase activity and globotriaosylceramide isoforms in these patients.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective

Primary Outcomes

Measure
Prevalence of Anderson - Fabry disease
time frame: 2 years

Eligibility Criteria

Male or female participants from 18 years up to 90 years old.

Inclusion Criteria: - Patients with myocardial septum wall thickness ≥ 12mm Exclusion Criteria: - Patients < 18 years - Patients unable to provide urine sample

Additional Information

Official title Prevalence of Anderson - Fabry Disease in Patients With Left Ventricular Hypertrophy
Principal investigator Gerald Mundigler, MD
Description Anderson - Fabry disease (AFD) is a rare, X - linked hereditary systemic lysosomal storage disorder which usually affects the heart. The reported incidence of AFD is between 1 in 117000 and 1 in 240000 live births. Due to a deficiency of the enzyme α - galactosidase, glycosphingo-lipids, primarily globotriaosylceramide, are stored also in endothelial and myocardial cells, leading to morphologic and functional changes. AFD-cardiomyopathy progresses with age and with the course of the disease, leading to reduced life expectancy. The investigators hypothesize, that AFD could be underdiagnosed in patients with only mild or moderate left ventricular myocardial hypertrophy. Early diagnosis of AFD may be relevant since affected patients might benefit from enzyme replacement therapy at early stage of disease. The investigators will examine 4000 consecutive patients with an echocardiographically measured interventricular septum thickness of ≥ 12mm. Urine samples will be collected and Gb3-isoforms, creatinine and α - Galactosidase activity will be measured.
Trial information was received from ClinicalTrials.gov and was last updated in July 2011.
Information provided to ClinicalTrials.gov by Medical University of Vienna.