Early Detection of Arteriosclerosis
This trial is active, not recruiting.
|Conditions||arteriosclerosis, atherosclerosis, myocardial infarction, stroke, diabetes mellitus, peripheral arterial occlusive disease|
|Sponsor||Kantonsspital Baselland Bruderholz|
|Start date||October 2003|
|End date||October 2015|
|Trial size||269 participants|
|Trial identifier||NCT00863967, KSBH: 216/03|
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.
Objective: Improve individual risk prediction by clinical phenotyping and genotyping.
no cardiovascular events
proven cardiovascular events
possible cardiovascular events
time frame: 10 years at least
Disease activity score
time frame: 2 / 5 / 10 years
Male or female participants at least 18 years old.
- 18 years and older
- informed consent
- life-threatening disease
- life expectancy < 1 month
- uncapable to provide informed consent
|Official title||Prospective Observational Cohort Study for Early Detection of Arteriosclerosis|
|Principal investigator||Barbara Biedermann, MD|
|Description||About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations. At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.|
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