This trial is active, not recruiting.

Conditions arteriosclerosis, atherosclerosis, myocardial infarction, stroke, diabetes mellitus, peripheral arterial occlusive disease
Sponsor Kantonsspital Baselland Bruderholz
Start date October 2003
End date October 2015
Trial size 269 participants
Trial identifier NCT00863967, KSBH: 216/03


Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.

Objective: Improve individual risk prediction by clinical phenotyping and genotyping.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
no cardiovascular events
proven cardiovascular events
possible cardiovascular events

Primary Outcomes

Cardiovascular events
time frame: 10 years at least

Secondary Outcomes

Disease activity score
time frame: 2 / 5 / 10 years

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - 18 years and older - informed consent Exclusion Criteria: - life-threatening disease - life expectancy < 1 month - uncapable to provide informed consent

Additional Information

Official title Prospective Observational Cohort Study for Early Detection of Arteriosclerosis
Principal investigator Barbara Biedermann, MD
Description About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations. At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.
Trial information was received from ClinicalTrials.gov and was last updated in March 2009.
Information provided to ClinicalTrials.gov by Kantonsspital Baselland Bruderholz.