Overview

This trial is active, not recruiting.

Conditions type 2 diabetes, impaired glucose tolerance
Treatment exercise
Sponsor Karolinska Institutet
Start date April 2006
End date September 2009
Trial size 213 participants
Trial identifier NCT00852982, ALF 2006 03 25

Summary

A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity. Effects on quality of life, cardiovascular risk factors and functions in muscle cells will be determined.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose prevention
Arm
(Experimental)
Five hours of Nordic walking per week, during four months
exercise
Nordic walking, with walking poles, five hours per week during four months
(No Intervention)
Control group asked not to alter lifestyle during study
exercise
Nordic walking, with walking poles, five hours per week during four months

Primary Outcomes

Measure
HbA1c
time frame: at inclusion and after four months

Secondary Outcomes

Measure
waist circumference
time frame: at inclusion and after four months

Eligibility Criteria

Male or female participants from 45 years up to 69 years old.

Inclusion Criteria: - BMI>25 Exclusion Criteria: - Physical impairment - Symptomatic angina pectoris - Insulin treatment

Additional Information

Official title Exercise - Effects on Health Related Quality of Life, Cardiovascular Risk Factors, and Cellular Functions With Respect to Glucose Metabolism, in Type 2 Diabetes Mellitus, Impaired Glucose Tolerance and in Healthy Individuals.
Principal investigator Juleen Zierath, Professor
Description Regular physical activity is known to have a beneficial effect on several factors affecting the risk of developing cardiovascular disease and type 2 diabetes. Implementing and maintaining changes of lifestyle is, however, known to be difficult. In this study we wished to investigate the effects of an exercise intervention that is feasible to most people with type 2 diabetes or at risk of developing that disease. The intervention was Nordic walking (with walking poles) for five hour per week, during four months. We chose to determine effects on health related quality of life, clinical parameters related to body weight/body composition, blood pressure, glucose metabolism, insulin resistance, blood lipids, oxygen uptake and physiological effects in skeletal muscle cells related to glucose metabolism. On inclusion and after four months the participants were therefore subject to clinical measurements, blood samples, maximal oxygen uptake tests on an ergometer cycle and muscle biopsies at inclusion and after four months of participation. They also answered an extensive questionnaire focusing on health related quality of life.
Trial information was received from ClinicalTrials.gov and was last updated in February 2009.
Information provided to ClinicalTrials.gov by Karolinska Institutet.