Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair
This trial is active, not recruiting.
|Conditions||aortic diseases, osteoarthritis, hip|
|Treatment||sangvia blood sampling system|
|Sponsor||Sykehuset i Vestfold HF|
|Collaborator||Oslo University Hospital|
|Start date||November 2009|
|End date||February 2010|
|Trial size||20 participants|
|Trial identifier||NCT00851149, 6.2009.36|
The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?
|Observational model||case control|
Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.
time frame: 30 days
Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.
time frame: 30 days
Male or female participants at least 18 years old.
- ASA 1-4
- Patient using corticosteroids, NSAIDs or Cox-II inhibitors
- Patients under 18 years
- Patients who are included in pharmaceutical studies
- Opioids-, benzodiazepines-, antiepileptic drugs-, alcohol- and α2-agonists abuse
- Pregnant and breastfeeding women
- Patients with known hypersensitivity for opioids, propofol or volatile anesthetics
- Patients with serious arrhythmias (atrial fibrillation/flutter is acceptable)
- Uncontrolled hypertension, serious psychiatric disease
- Patients with unstable angina pectoris or myocardial infarction the last month before inclusion
- Acute abdominal aortic surgery (acute dissection or rupture)
- Planned laparoscopic abdominal aortic aneurysm surgery
- Transfusion of blood products last month before surgery
- Glucocorticoid users
|Official title||Pro-inflammatory Cytokines (IL-1beta,IL-6, IL-8 and TNF-α) and Complement Activation (C3a) in Blood Collected From Surgery Field From Patients Undergoing Orthopedic Surgery Compared to Patients Undergoing Abdominal Aneurysm Repair.|
|Principal investigator||Espen Lindholm, Md|
|Description||Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery. Primary outcome: Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups. Secondary outcome: Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.|
Call for more information