Overview

This trial is active, not recruiting.

Conditions hiv infection, inflammation, cardiovascular disease, hiv infections
Treatments raltegravir, placebo
Sponsor University of California, San Francisco
Collaborator National Heart, Lung, and Blood Institute (NHLBI)
Start date January 2009
End date November 2013
Trial size 50 participants
Trial identifier NCT00843713, 1R01HL095130-01

Summary

Recent studies suggest that HIV patients are at increased risk for cardiovascular events; however, the mechanisms underlying this increased risk remain unclear. Our group was one of the first to demonstrate that HIV infection is independently associated with accelerated atherosclerosis, as measured by carotid artery-intima media thickness (IMT), and that HIV-associated inflammation may be driving this accelerated atherosclerosis. The mechanism by which HIV disease independent of any drug-specific toxicity increases the risk of cardiovascular disease during HAART is not known. We hypothesize that even well controlled HIV infection is independently associated with cardiovascular risk and that further decreasing HIV-associated inflammation adding newer antiretroviral agents will also decrease cardiovascular risk.

We will perform a small clinical trial of approximately 50 HIV-infected patients each to study the relationship between HIV infection, inflammation, thrombosis, atherogenic lipoproteins, and measures of atherosclerosis. We propose the following specific aims: Aim 1: To determine the influence of traditional and novel markers of inflammation on endothelial function and IMT progression; Aim 2: To determine if "intensification" with raltegravir in subjects on long-term antiretroviral therapy with clinically undetectable HIV RNA levels will improve endothelial function, and to determine if this effect is mediated by alterations in inflammatory markers, lipoproteins and/or thrombotic factors. For Aim 2, subjects from 2 randomized, double-blind, placebo-controlled raltegravir intensification studies will be asked to co-enroll in this cardiovascular study.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Intervention model single group assignment
Masking double blind (subject, caregiver, investigator, outcomes assessor)
Primary purpose treatment
Arm
(Placebo Comparator)
For subjects assigned to the placebo group, patients will take a matching placebo pill of 400 mg by mouth twice daily for 24 weeks in addition to taking their current HIV medication
placebo
For the patient assigned to the placebo group, subjects will take a matching placebo pill 400mg to be taken by mouth twice daily for 24 weeks in addition to taking their current HIV medication
(Active Comparator)
For subjects assigned to the active comparator group, they will receive raltegravir at 400 mg by mouth twice daily for 24 weeks in addition to continuing to take their current HIV medication
raltegravir
For patients assigned to the raltegravir group, subjects will receive raltegravir 400mg to be taken by mouth twice daily for 24 weeks in addition to taking their current HIV medication

Primary Outcomes

Measure
endothelial function
time frame: 24 weeks
Primary virologic outcome: Increase in 2-LTR circles at weeks 1 or 2 (immunologic responders, n=31)
time frame: 24 weeks

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: 1. Stable antiretroviral therapy for at least 12 months 2. All plasma HIV RNA levels within the past year must be below level of detection (< 50 copies RNA/mL), although isolated single values > 50 but < 200 copies will be allowed. 3. Screening plasma HIV RNA levels < 50 copies RNA/mL 4. >90% adherence to therapy within the preceding 30 days, as determined by self-report 5. Females of childbearing potential must have a negative serum pregnancy test at screening and agree to use a double-barrier method of contraception throughout the study period. 6. CD4<350 cells/mm3 for at least one year ("immunologic non-responder") or CD4>=350 cells/mm3 for at least one year ("immunologic responder"). Exclusion Criteria: 1. Ongoing or prior use of any integrase inhibitor or R5 inhibitor. 2. Patients who plan to modify existing antiretroviral therapy in the next 24 weeks for any reason 3. Serious illness requiring hospitalization or parental antibiotics within preceding 3 months 4. Concurrent or recent exposure to any immunomodulatory drugs 5. Advanced liver disease or active hepatitis B or C 6. Patients with systolic blood pressure <100/70 7. Starting or stopping statin therapy during the trial

Additional Information

Principal investigator Priscilla Hsue, MD
Trial information was received from ClinicalTrials.gov and was last updated in November 2013.
Information provided to ClinicalTrials.gov by University of California, San Francisco.