This trial is active, not recruiting.

Condition cardiopulmonary arrest outcome
Sponsor Shaare Zedek Medical Center
Start date August 2008
End date March 2017
Trial size 313 participants
Trial identifier NCT00814814, 14-01-05 A and B (correction)


Management of cardiac arrest is complicated by the lack of a readily available tool identifying individuals who are likely to be successfully resuscitated. S100 beta is a protein that originates in the astroglial cells of the brain, and NSE (Neuron Specific Enolase) is another protein that originates in the neurons themselves. In the laboratory, the concentration of these proteins correlate with evidence of brain damage after head trauma, stroke and exposure to low levels of oxygen. The concentration of these proteins in the blood of human survivors of cardiopulmonary resuscitation in humans is much higher than in patients who were resuscitated but did not survive. However, it is still unclear whether survivors from cardiopulmonary resuscitation have higher levels of these proteins in their blood if they survive with neurological injury secondary to the arrest and resuscitation.

Hypothesis: In humans, the blood concentrations of protein S100 beta and NSE during and after resuscitation can predict who will die despite cardiopulmonary resuscitation and who will survive with neurological injury secondary to the arrest and resuscitation.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort

Primary Outcomes

Poor versus good patient outcome at discharge was used to test the study hypotheses of improved prediction attributable to S100B and NSE concentration.
time frame: within 24 hours of discharge

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - All victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the Jerusalem district. Exclusion Criteria: - Patients with do-not-resuscitate orders or an advance directive to that effect. - Patients with intracranial hemorrhage

Additional Information

Official title Protein S100 Beta as a Predictor of the Outcome of Cardiopulmonary Resuscitation
Principal investigator Sharon Einav, MD
Trial information was received from ClinicalTrials.gov and was last updated in April 2016.
Information provided to ClinicalTrials.gov by Shaare Zedek Medical Center.