Overview

This trial is active, not recruiting.

Conditions colorectal liver metastases, hepatocellular carcinoma, liver malignancies
Treatment anatomical right posterior sectionectomy of the liver by ious-guided finger compression.
Sponsor University of Milan
Start date September 2007
End date January 2009
Trial size 10 participants
Trial identifier NCT00797251, IOUS-Compression

Summary

The use of intraoperative ultrasound (IOUS) allows us to perform new conservative hepatectomies. The investigators previously reported the systematic subsegmentectomy by IOUS-guided finger compression for segments 2-3, which is currently applied for patients with hepatocellular carcinoma (HCC)on cirrhosis. The investigators herein describe a novel technique, which consists in the systematic right posterior sectionectomy by IOUS-guided finger compression.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Patients with tumors in the right posterior section of the liver (segments 6-7)
anatomical right posterior sectionectomy of the liver by ious-guided finger compression. anatomic resection of segment 6-7
The technique consists in IOUS-guided finger compression of the right posterior portal pedicle at the level closest to the tumor but oncologically suitable. This method allows us to anatomically mark the area of resection with nor hilar plate nor IOUS-guided puncture of vessels, which are up to date the only two techniques available to perform anatomical right posterior sectionectomy - namely the removal of segment 6 and 7.

Primary Outcomes

Measure
The primary outcome is the safety of the anatomical right posterior sectionectomy performed IOUS-guided finger compression.
time frame: 6 months

Secondary Outcomes

Measure
The secondary outcome is the efficacy of the anatomical right posterior sectionectomy performed by IOUS-guided finger compression.
time frame: 1 year

Eligibility Criteria

Male or female participants from 18 years up to 85 years old.

Inclusion Criteria: - Patients with tumors at least at 1 cm distally to the bifurcation of the right portal vein (bifurcation of P5-8 and P6-7) eligible for right posterior sectionectomy, namely the anatomical removal of segment 6 and 7, were considered potential candidates to this procedure. Precisely, these criteria were adopted: - Patients with hepatocellular carcinoma (HCC) with infiltrative growing pattern in contact with P6-7; - Patients with any type of HCC in contact with P6-7 with distal bile duct dilation; - Patients with colorectal liver metastasis (CLM) in contact with P6-7. Exclusion Criteria: - Exclusion criteria for carrying out the herein described procedure was considered the presence of tumoral thrombosis in P6-7.

Additional Information

Official title A Novel Simple Technique for Performing Anatomical Right Posterior Sectionectomy of the Liver: the Ultrasound-Guided Finger Compression
Principal investigator Guido Torzilli, MD, PhD
Description A novel technique for the demarcation of the resection area by means of IOUS-guided finger compression to accomplish a right posterior sectionectomy is described. Dissection or encirclement of the sectional pedicles for resection area demarcation is thus avoided. Ten patients underwent this technique successfully without mortality or major morbidity. IOUS-guided finger compression of sectional portal pedicle feeding the right posterior section is a feasible, safe, and effective method.
Trial information was received from ClinicalTrials.gov and was last updated in November 2008.
Information provided to ClinicalTrials.gov by University of Milan.