Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus
This trial is active, not recruiting.
|Conditions||dry eye syndromes, hiv seropositivity|
|Treatments||cyclosporine and sodium carboximethycellulose, sodium carboximethycellulose|
|Sponsor||Universidade Federal do Rio de Janeiro|
|Start date||October 2006|
|End date||July 2008|
|Trial size||20 participants|
|Trial identifier||NCT00797030, dry eye|
This study evaluates the use of topical cyclosporine 0.05% and sodium carboxymethylcellulose 0.5% for the treatment of dry eye disease in patients infected with the human immunodeficiency virus.
Twenty HIV-positive-patients were selected from the Department of Infectious Diseases of the Federal University of Rio de Janeiro Hospital. Dry eye diagnosis was based on a dry eye questionnaire (Ocular Surface Disease Index - OSDI®), Schirmer I Test, break up time and 1% rose bengal staining of the ocular surface. The patients were divided into two groups with ten patients. Group I received sodium carboxymethylcellulose 0.5% drops and group II received sodium carboxymethylcellulose 0,5% drops and topical cyclosporine 0.05% for six months.
|Intervention model||parallel assignment|
Dry eye diagnosis was based on a dry eye questionnaire (OSDI), Shirmer I Test, BUT and 1% rose bengal staining of the ocular surface. The same tests were performed at the end of the treatment to verify the improvement of the subjects.
time frame: six months
Male or female participants from 18 years up to 45 years old.
Inclusion Criteria: - HIV seropositivity - Dry eye diagnosis Exclusion Criteria: - Hepatitis B infection - Hepatitis C infection - Menopause - Rheumatic diseases - Contact lens wear - Beta-blocker eye drops - Blepharitis - Use of medications associated with dry eye (diuretics, antidepressive agents, beta-blockers)
|Official title||Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus|
|Principal investigator||Rodrigo P Barreto, Masters|
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