Magnetic Resonance Imaging (MRI) and Quantitative MR Cerebral Spinal Fluid (CSF) Flow Studies in Craniovertebral Junction Anomalies
This trial is active, not recruiting.
|Treatment||dynamic cervical mri scans|
|Sponsor||University of Michigan|
|Start date||July 2012|
|End date||December 2016|
|Trial size||40 participants|
|Trial identifier||NCT00795080, HUM 18481|
The purpose of this study is to decide which position of the neck affects cerebral spinal fluid (CSF) flow between the spinal cord and the brain. CSF is a fluid that flows up and down your spinal cord, around the brain and into the ventricles of the brain.
|Observational model||case control|
To compare changes in flow velocities at the CVJ and aqueduct of Sylvius w/dynamic imaging in normal controls and in patients with symptomatic and asymptomatic Chiari 1 malformations and similar anomalies.
time frame: 1 year
Results from the primary outcome will be correlated with post operative changes in a subset of patients as a predictor for surgical outcomes.
time frame: 1 year
Male or female participants at least 12 years old.
Inclusion Criteria: - Healthy volunteers must be 18 yrs of age or older. - Patients w/Chiari 1 or CVJ malformations must be 12 yrs of age or older, - Who can cooperate in flexing and extending their neck within the cervical spine coil used for MR Imaging. - Pediatric patients will be included only if they can cooperate for the additional sequences for the study and will not require sedation or any form of anesthesia. Exclusion Criteria: - Patients who are medically unstable or cannot voluntarily flex or extend their necks. - Patients' hardware placed in the head or necks which are incompatible with MR imaging. - Patient requiring any form of sedation which can lead to compromise of the airway with maneuvers described above. - History of prior head trauma or history of neurological conditions which can lead to altered CSF dynamics that can interfere with the outcome of this study.
|Official title||Dynamic Magnetic Resonance Imaging (MRI) and Quantitative MR Cerebral Spinal Fluid (CSF) Flow Studies in Craniovertebral Junction Anomalies|
|Principal investigator||Rajiv Bapuraj, M.D., MD|
|Description||To perform dynamic cervical magnetic resonance imaging (MRI) of the craniovertebral junction (CVJ) coupled with CSF flow studies to assess changes in CSF flow velocities with changing position of the neck at the CVJ and aqueduct of Sylvius in patients with Chiari 1 malformations and similar malformations fo the CVJ leading to inherent instability in this region, and determine if there is any correlation of these findings to clinical outcome.|
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