Vascular Sensitivity to Adrenergic Agonists in Patients With CHF and in Healthy Subjects
This trial is active, not recruiting.
|Condition||congestive heart failure|
|Sponsor||Hadassah Medical Organization|
|Start date||August 2008|
|End date||December 2009|
|Trial size||80 participants|
|Trial identifier||NCT00782782, 366-28.12.07|
Congestive Heart failure (CHF) is asociated with changes in cardiac function and vascular responses. The aim of this study is to characterize these differences. Our hypothesis is, that there are differences in vascular responses between healthy subjects and patients with CHF.
|Observational model||case control|
vascular sensitivity (ED50) and response (Emax) to dexmedetomidine, phenylephrine, isoproterenol and terbutaline
time frame: 3 weeks
Male or female participants from 18 years up to 70 years old.
Inclusion Criteria: - Patients with congestive heart failure NYHA I-II - Stable clinical condition Exclusion Criteria: - Resting systolic blood pressure < 100 - Resting heart rate < 50 - Hypersensitivity to dexmedetomidine, phenylephrine, isoproterenol, terbutaline
|Official title||Effect of Medications on Vascular Response in Patients With CHF and in Healthy Subjects|
|Principal investigator||Mordechai Muszkat|
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