Sex and Obesity: Effects on Heart Failure Study
This trial is active, not recruiting.
|Conditions||obesity, heart failure|
|Treatments||pet (positron emission tomography), echocardiogram, vo2 peak test, body composition study, 15o water, 11c acetate, 11c palmitate, 11c glucose|
|Sponsor||Washington University School of Medicine|
|Start date||January 2008|
|End date||February 2017|
|Trial size||10 participants|
|Trial identifier||NCT00776035, 07-1128|
Sex has a major impact on myocardial metabolism and blood flow. In subjects without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow.
Obesity is a major risk factor for Heart Failure. In subjects without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men.
To measure blood flow and metabolism we will be using radioactive materials and a PET (positron emission Tomography)scan to study the metabolism of the heart.
Hypotheses: 1) Women with nonischemic heart failure will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with nonischemic heart failure 2) Patients with obesity-related HF have a myocardial metabolic profile that is similar to that of obese subjects without heart failure and different (higher FA metabolism) from that of nonobese Heart failure patients.
Myocardial blood flow, glucose metabolism, oxygen metabolism, and fat metabolism
time frame: the time frame of the study
Male or female participants from 20 years up to 65 years old.
Inclusion Criteria: men and women - Non Ischemic Heart failure, ejection fraction <40%, premenopausal, Obese(BMI >30),Lean, age 20-50, non diabetic Exclusion Criteria: - Pregnancy, lactating, actively losing weight, nonsedentary, greater than Class I hypertension,require alterations in heart medications, Diabetics.
|Official title||Sex and Obesity Effects on Myocardial Blood Flow and Metabolism|
|Principal investigator||Linda Peterson, MD|
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