This trial is active, not recruiting.

Conditions obesity, heart failure
Treatments pet (positron emission tomography), echocardiogram, vo2 peak test, body composition study, 15o water, 11c acetate, 11c palmitate, 11c glucose
Sponsor Washington University School of Medicine
Collaborator Barnes-Jewish Hospital
Start date January 2008
End date February 2017
Trial size 10 participants
Trial identifier NCT00776035, 07-1128


Sex has a major impact on myocardial metabolism and blood flow. In subjects without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow.

Obesity is a major risk factor for Heart Failure. In subjects without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men.

To measure blood flow and metabolism we will be using radioactive materials and a PET (positron emission Tomography)scan to study the metabolism of the heart.

Hypotheses: 1) Women with nonischemic heart failure will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with nonischemic heart failure 2) Patients with obesity-related HF have a myocardial metabolic profile that is similar to that of obese subjects without heart failure and different (higher FA metabolism) from that of nonobese Heart failure patients.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Time perspective prospective
Obesity related Heart failure population
pet (positron emission tomography) PET scan
this is a diagnostic scan that requires the injection of radioactive tracers into an IV placed in the arm.
echocardiogram Echo
an ultrasound of the heart
vo2 peak test
walking on a treadmill during which you will breath in and out through a tube
body composition study DEXA scan
a scan of your entire body measuring Body Mass Index, fat percentage etc...
15o water
radioactive tracer used to study blood flow during the PET scan
11c acetate
radioactive tracer that helps study heart metabolism
11c palmitate
radioactive tracer used to study fatty acid usage in the heart
11c glucose
radioactive tracer usde to study glucose usage in the heart

Primary Outcomes

Myocardial blood flow, glucose metabolism, oxygen metabolism, and fat metabolism
time frame: the time frame of the study

Eligibility Criteria

Male or female participants from 20 years up to 65 years old.

Inclusion Criteria: men and women - Non Ischemic Heart failure, ejection fraction <40%, premenopausal, Obese(BMI >30),Lean, age 20-50, non diabetic Exclusion Criteria: - Pregnancy, lactating, actively losing weight, nonsedentary, greater than Class I hypertension,require alterations in heart medications, Diabetics.

Additional Information

Official title Sex and Obesity Effects on Myocardial Blood Flow and Metabolism
Principal investigator Linda Peterson, MD
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by Washington University School of Medicine.