This trial is active, not recruiting.

Condition periodontal diseases
Treatments triclosan, fluoride
Phase phase 3
Sponsor Colgate Palmolive
Start date November 2000
End date December 2009
Trial size 438 participants
Trial identifier NCT00763165, D/06/Dent/99


To access the influence of triclosan dentifrice on the progression of periodontal disease in patients with coronary heart disease.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking double blind (subject, investigator)
Primary purpose treatment
(Active Comparator)
Brush twice daily
Brush twice daily
(Placebo Comparator)
Brush twice daily

Primary Outcomes

Periodontal disease
time frame: 3-5 Years

Eligibility Criteria

Male or female participants from 18 years up to 75 years old.

Inclusion Criteria: - A minimum of 12 uncrowned teeth other than 3rd molars - Age 18 to 75 years - Informed consent Exclusion Criteria: - Prosthetic heart valves - Prosthetic joint replacement - Previous infective endocarditis - Requirement for antibiotic cover for dental treatment - Current treatment with warfarin

Additional Information

Official title Periodontal Disease and Cardiovascular Disease
Principal investigator Gregory Seymour, BDS
Trial information was received from ClinicalTrials.gov and was last updated in September 2008.
Information provided to ClinicalTrials.gov by Colgate Palmolive.