Spine Quantitative Computed Tomography (QCT)
This trial is active, not recruiting.
|Condition||juvenile idiopathic arthritis|
|Sponsor||Children's Hospital of Philadelphia|
|Start date||April 2008|
|End date||January 2014|
|Trial size||127 participants|
|Trial identifier||NCT00762879, 2007-10-5528|
The purpose of this study is to compare healthy children to children who have a chronic illness called Juvenile Idiopathic Arthritis (JIA). JIA is a childhood disease that causes swollen joints that are often stiff and painful. JIA affects about 1 in 1,000 children age 16 and younger.
|Observational model||case control|
Lumbar spine volumetric Bone Mineral Density (vBMD) and vertebral size will vary according to sex, age and pubertal stage.
time frame: same day
Children with JIA will have lower vertebral stiffness and strength, compared with controls.
time frame: same day
Male or female participants from 5 years up to 21 years old.
Inclusion Criteria: - for JIA patients: subjects age 5-21 Drawn from Dr. Burnham's prospective cohort study of bone health in 101 children with arthritis. - for Control patients: subjects age 5-21 Controls will be a 50% male/female Exclusion Criteria: - for JIA patients: Subjects with JIA will be excluded if they have conditions or drug exposure unrelated to JIA and known to impact growth or bone health. - for Control patients: Chronic disease or syndrome known to affect growth or bone health, prematurity (<37 weeks gestation), or use of any medication known to affect growth.
|Official title||Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children|
|Principal investigator||Jon Burnham, MD|
|Description||Children with chronic illnesses are at risk for bone fragility due to inflammation, glucocorticoid therapy, physical activity limitation, malnutrition, and pubertal delay. The impact of low bone mass during childhood may be immediate, resulting in childhood fractures, or delayed, due to suboptimal peak bone mass attainment.|
Call for more information