Overview

This trial is active, not recruiting.

Condition juvenile idiopathic arthritis
Sponsor Children's Hospital of Philadelphia
Start date April 2008
End date January 2014
Trial size 127 participants
Trial identifier NCT00762879, 2007-10-5528

Summary

The purpose of this study is to compare healthy children to children who have a chronic illness called Juvenile Idiopathic Arthritis (JIA). JIA is a childhood disease that causes swollen joints that are often stiff and painful. JIA affects about 1 in 1,000 children age 16 and younger.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
Arm

Primary Outcomes

Measure
Lumbar spine volumetric Bone Mineral Density (vBMD) and vertebral size will vary according to sex, age and pubertal stage.
time frame: same day

Secondary Outcomes

Measure
Children with JIA will have lower vertebral stiffness and strength, compared with controls.
time frame: same day

Eligibility Criteria

Male or female participants from 5 years up to 21 years old.

Inclusion Criteria: - for JIA patients: subjects age 5-21 Drawn from Dr. Burnham's prospective cohort study of bone health in 101 children with arthritis. - for Control patients: subjects age 5-21 Controls will be a 50% male/female Exclusion Criteria: - for JIA patients: Subjects with JIA will be excluded if they have conditions or drug exposure unrelated to JIA and known to impact growth or bone health. - for Control patients: Chronic disease or syndrome known to affect growth or bone health, prematurity (<37 weeks gestation), or use of any medication known to affect growth.

Additional Information

Official title Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children
Principal investigator Jon Burnham, MD
Description Children with chronic illnesses are at risk for bone fragility due to inflammation, glucocorticoid therapy, physical activity limitation, malnutrition, and pubertal delay. The impact of low bone mass during childhood may be immediate, resulting in childhood fractures, or delayed, due to suboptimal peak bone mass attainment.
Trial information was received from ClinicalTrials.gov and was last updated in July 2016.
Information provided to ClinicalTrials.gov by Children's Hospital of Philadelphia.