This trial is active, not recruiting.

Condition sleep apnea syndrome
Treatment chronic intermittent hypoxia
Sponsor University Hospital, Grenoble
Start date September 2005
End date July 2007
Trial size 12 participants
Trial identifier NCT00746928, 05-CHUG-23


The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.

Precisely, the study was designed to :

Set up a new model of Chronic Intermittent Hypoxia (CIH) applied to healthy human. This CIH is mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome.

Evaluate the cardiovascular effect of CIH. Neuronal and humoral sympathetic control, blood pressure control, vascular resistance.

Evaluate the Sleep quality, the ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex).

Investigates the biological aspects of CIH exposure.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose basic science

Primary Outcomes

Blood Pressure
time frame: Two Weeks

Secondary Outcomes

Neuronal and humoral sympathetic control and vascular resistance.
time frame: Two weeks
Sleep quality
time frame: Two Weeks
The ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex)
time frame: two weeks

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Healthy subjects Exclusion Criteria: - Any history or significant medical condition

Additional Information

Official title Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
Principal investigator Renaud Tamisier, MD, PhD
Trial information was received from ClinicalTrials.gov and was last updated in September 2008.
Information provided to ClinicalTrials.gov by University Hospital, Grenoble.