Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae
This trial is active, not recruiting.
|Sponsor||Mashhad University of Medical Sciences|
|Collaborator||University of Tehran|
|Start date||May 2007|
|End date||August 2008|
|Trial size||30 participants|
|Trial identifier||NCT00723268, 286293|
The purpose of this study is to determine whether low doses of prednisolone, or colchicine are effective in the treatment of oral aphthae.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||single blind (investigator)|
frequency of ulcers
time frame: 1 year
Male or female participants from 15 years up to 60 years old.
Inclusion Criteria: - Confirmation of clinical diagnosis of aphthae - Having the experience of oral aphthae at least once in a month - Two weeks wash out periods after the last treatment Exclusion Criteria: - History of any systemic disease - Using drugs which affect immune system - Pregnancy and breast feeding - Aphthous related syndromes
|Official title||Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae|
|Description||Treatment of recurrent aphthous stomatitis (RAS) remains, to date, empirical and non-specific. The main goals of therapy are to minimize pain and functional disabilities as well as decrease inflammatory reactions and frequency of recurrences.|
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