This trial is active, not recruiting.

Condition oxidative stress
Treatments angel's plant (angelica keiskei)
Phase phase 0
Sponsor Tufts University
Start date July 2008
End date March 2009
Trial size 10 participants
Trial identifier NCT00721643, BioGreen 20070301034009, HNRCA2580


The absorption kinetics of polyphenols in angel's plant (Angelica keiskei), which is a dark green leafy vegetable rich in antioxidant nutrients, will be determined in older adults in this pilot study.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation non-randomized
Endpoint classification bio-availability study
Intervention model single group assignment
Masking open label
Primary purpose basic science
Healthy control, 5g dry power of angel's plant (Angelica keiskei)
angel's plant (angelica keiskei)
Healthy control, one time dose of 5g dry power of Angelica keiskei
Metabolic syndrome, 5g dry powder of angel's plant (Angelica keiskei)
angel's plant (angelica keiskei)
Metaboic syndrome subjects, one time dose of 5g dry powder of angel's plant (Angelica keiskei)

Primary Outcomes

Plasma quercetin
time frame: 0, 30, 60, 100, 180, 240, 300, 360, 420 & 480 min

Eligibility Criteria

Male or female participants at least 60 years old.

Inclusion Criteria: - Healthy subjects (>60 yr, n=5) - subjects with metabolic syndrome (>60 yr, n=5) - Subjects who has - high fasting plasma glucose (>5.6 mmol/L), - central obesity (waist-hip ratio, >0.9 for men, >0.85 for women) - either high blood pressure (>130/85 mmHg) or high triacylglycerol (>1.7 mmol/L) will be selected to have metabolic syndrome. - normal hematological parameters, normal serum albumin, normal liver function, and normal kidney function - no history of smoking or alcoholism. Exclusion Criteria: - consume >7 alcoholic drinks/wk - taking cholesterol medication or hormone replacement

Additional Information

Official title Absorption Kinetics of Polyphenols in Angel's Plant (Angelica Keiskei)
Principal investigator Kyung-Jin Yeum, Ph.D.
Trial information was received from ClinicalTrials.gov and was last updated in August 2009.
Information provided to ClinicalTrials.gov by Tufts University.