This trial is active, not recruiting.

Condition borderline personality disorder
Treatments transference-focused psychotherapy, treatment by experienced community psychotherapists
Sponsor University Hospital Muenster
Start date October 2004
End date February 2009
Trial size 104 participants
Trial identifier NCT00714311, 10636, 1106/04, DPG0802


The purpose of this study is to find out whether Transference-Focused Psychotherapy (TFP) is effective in the treatment of Borderline Personality Disorder.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking single blind (outcomes assessor)
Primary purpose treatment
(Active Comparator)
Transference-Focused Psychotherapy
transference-focused psychotherapy
Outpatient psychotherapy according to the treatment manual, sessions of 50 minutes twice per week
(Active Comparator)
treatment by experienced community psychotherapists
treatment by experienced community psychotherapists
Outpatient psychotherapy in private practices or outpatient units of psychiatric hospitals. Licensed psychotherapists with experience and special interest in the treatment of borderline patients are treating according to the method they have learned.

Primary Outcomes

time frame: 1 year
Suicidality (suicide attempts)
time frame: 1 year

Secondary Outcomes

Psychosocial Functioning (Global Assessment of Functioning, GAF-Score)
time frame: 1 year
Level of personality organization (Structured Interview for Personality Organization, STIPO)
time frame: 1 year
Number of self-harming acts
time frame: 1 year
Self-assessment of psychopathology (BDI, STAI, BSI)
time frame: 1 year
Attachment style and Reflective Function (Adult Attachment Interview, AAI)
time frame: 1 year
Borderline symptomatology (DSM-IV criteria)
time frame: 1 month

Eligibility Criteria

Female participants from 18 years up to 45 years old.

Inclusion Criteria: - Written informed consent to the participation in the study - Diagnosis of BPD according to DSM-IV as assessed using the SCID-II - Age between 18 and 45 years - Sufficient knowledge of the German language Exclusion Criteria: - Diagnosis of schizophrenia, bipolar disorder, severe substance abuse, organic pathology, or mental retardation according to DSM-IV as assessed using the SCID-I - Diagnosis of antisocial personality disorder according to DSM-IV as assessed using the SCID-II

Additional Information

Official title A Randomized-Controlled Trial of Transference-Focused Psychotherapy vs. Treatment by Experienced Community Psychotherapists for Borderline Personality Disorder
Principal investigator Stephan Doering, MD
Description Borderline personality disorder represents a sever clinical condition that affects 1-2% of the community and is characterized by a pervasive instability of interpersonal relationships, self-image, and affects, as well as a marked impulsivity; up to 10% of the patients commit suicide. Transference-Focused Psychotherapy (TFP) is one psychotherapeutic approach among five that have been manualized and evaluated in RCTs. So far, TFP has not been compared to a control condition which is a crucial step in the evaluation of the efficacy of a psychosocial intervention. This study is an RCT that compares one year of outpatient TFP to treatment by experienced community psychotherapists for borderline personality disorder.
Trial information was received from ClinicalTrials.gov and was last updated in February 2009.
Information provided to ClinicalTrials.gov by University Hospital Muenster.