This trial is active, not recruiting.

Conditions dilated cardiomyopathy, hypertrophic cardiomyopathy, mitochondrial cardiomyopathy, noncompaction cardiomyopathy, restrictive cardiomyopathy
Sponsor University of California, Irvine
Start date April 2007
End date January 2015
Trial size 200 participants
Trial identifier NCT00703443, HS# 2007-5577, NIH/NHLBI 5K08HL081222-02


The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model family-based
Time perspective retrospective

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Individuals with a diagnosis of cardiomyopathy - Family members of individuals with a diagnosis of cardiomyopathy - Individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy Exclusion Criteria: - Individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy

Additional Information

Official title The Genetics of Cardiomyopathy and Heart Failure
Principal investigator Michael V Zaragoza, M.D., Ph.D.
Description The purpose of this research study is to explore the causes and inheritances of cardiomyopathies. Cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. The underlying genetics of cardiomyopathies are poorly understood. This study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. This information will be used to identify inheritance patterns within families with cardiomyopathies. In addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. Overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.
Trial information was received from ClinicalTrials.gov and was last updated in February 2010.
Information provided to ClinicalTrials.gov by University of California, Irvine.