The Genetics of Cardiomyopathy and Heart Failure
This trial is active, not recruiting.
|Conditions||dilated cardiomyopathy, hypertrophic cardiomyopathy, mitochondrial cardiomyopathy, noncompaction cardiomyopathy, restrictive cardiomyopathy|
|Sponsor||University of California, Irvine|
|Start date||April 2007|
|End date||January 2015|
|Trial size||200 participants|
|Trial identifier||NCT00703443, HS# 2007-5577, NIH/NHLBI 5K08HL081222-02|
The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.
Male or female participants of any age.
Inclusion Criteria: - Individuals with a diagnosis of cardiomyopathy - Family members of individuals with a diagnosis of cardiomyopathy - Individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy Exclusion Criteria: - Individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy
|Official title||The Genetics of Cardiomyopathy and Heart Failure|
|Principal investigator||Michael V Zaragoza, M.D., Ph.D.|
|Description||The purpose of this research study is to explore the causes and inheritances of cardiomyopathies. Cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. The underlying genetics of cardiomyopathies are poorly understood. This study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. This information will be used to identify inheritance patterns within families with cardiomyopathies. In addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. Overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.|
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