Evaluation of the Brain Natriuretic Peptide as a Predictor of Morbidity and Mortality in Cardiac Surgery
This trial is active, not recruiting.
|Conditions||coronary artery disease, valvular disease|
|Sponsor||University Hospital, Strasbourg, France|
|Start date||June 2008|
|End date||June 2017|
|Trial size||500 participants|
|Trial identifier||NCT00699673, 3910|
Objective: The purpose of the present study is to assess if perioperative variation of Brain Natriuretic Peptide (BNP) levels is a predictor of mortality and morbidity after cardiac surgery.Material and Methods: 500 consecutive patients will be enrolled prospectively in this study before cardiac surgery under cardiopulmonary bypass. BNP levels will be measured prior to surgery and at postoperative day 1. Variations of BNP levels will be analyzed to determine if it is a predictor of mortality and morbidity after cardiac surgery. This dynamic evaluation will be compared to other tools of risk stratification in cardiac surgery as the EuroScore. All patients will be followed 3 years after the procedure.
Hypothesis: Perioperative BNP variations may be more sensitive than pre- or postoperative BNP levels alone. Furthermore the perioperative homeostasis will be measured to assess its impact on BNP secretion during the perioperative period.
BNP levels; hospital and long-term morbidity and mortality
time frame: BNP levels prior to surgery and at postoperative day 1; Hospital and long-term morbidity and mortality (1, 2 and 3 years)
EuroScoreCardiac markers; inflammation markers; echocardiography
time frame: EuroScoreCardiac markers at day 1, 2, 5; Inflammation markers at day 1, 2, 5; Echocardiography (day 5, and 1, 2 and 3 years)
Male or female participants at least 18 years old.
Inclusion Criteria: - Patient who need cardiac surgery - Age > 18 years Exclusion Criteria: - Patient on mechanic ventilation before surgery - Aortic dissection-Congenital disease
|Official title||Evaluation of the Brain Natriuretic Peptide as a Predictor of Morbidity and Mortality in Cardiac Surgery|
|Principal investigator||Michel KINDO, MD|
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