This trial is active, not recruiting.

Conditions muscle quadriceps femoris, healthy
Treatment muscle activation
Sponsor German Research Foundation
Start date October 2008
End date October 2010
Trial size 60 participants
Trial identifier NCT00690547, DFG27112007


Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Time perspective prospective
muscle activation
activation of the muscle quadriceps femoris

Primary Outcomes

Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).
time frame: 12 months

Secondary Outcomes

Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation
time frame: 12 months
Correlation between typ of muscle fiber and force enhancement in vivo
time frame: 12 months
Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength
time frame: 12 months

Eligibility Criteria

Male participants from 20 years up to 40 years old.

Inclusion Criteria: - Males without previous muscular or neurophysiological diseases - Age between 20 and 40 years Exclusion Criteria: - Previous muscular or neurophysiological diseases

Additional Information

Official title Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.
Principal investigator Ansgar Schmirtz, Prof. Dr.
Description The research proposal is resubmitted with no amendments made regarding content.
Trial information was received from ClinicalTrials.gov and was last updated in November 2009.
Information provided to ClinicalTrials.gov by German Research Foundation.