Cognitive-Behavioral Therapy in Veterans With Schizophrenia
This trial is active, not recruiting.
|Conditions||schizophrenia, schizoaffective disorder|
|Treatments||supportive therapy, cognitive-behavioral therapy for psychosis|
|Sponsor||Department of Veterans Affairs|
|Start date||April 2009|
|End date||September 2014|
|Trial size||122 participants|
|Trial identifier||NCT00688259, MHBB-016-07S|
This is a study comparing the benefits of two types of individual psychotherapy (cognitive-behavioral therapy for psychosis and supportive therapy) in outpatients with schizophrenia or schizoaffective disorder. Treatment lasts 6 months and there are multiple assessment points.
|Endpoint classification||efficacy study|
|Intervention model||factorial assignment|
|Masking||single blind (outcomes assessor)|
BPRS, SAS, distress from symptoms
time frame: post-treatment and 6 month follow-up
Male or female participants from 18 years up to 70 years old.
Inclusion Criteria: - outpatients with schizophrenia or schizoaffective disorder in proximity to the West Los Angeles VAMC - at least one month since last hospitalization - stable antipsychotic medication persisting psychotic symptoms with at least minimal distress - competent to sign informed consent. Exclusion Criteria: - in other individual psychotherapy - presence of organic brain disease - mental retardation - or illness that would prohibit regular attendance in therapy - substance dependence diagnosis in the past 6 months.
|Official title||Cognitive-Behavioral Therapy in Veterans With Schizophrenia|
|Principal investigator||Shirley M. Glynn, PhD|
|Description||This is a randomized controlled trial comparing 6 months of participation in one of two active treatments, cognitive-behavior therapy for psychosis or supportive therapy. Assessments of clinical status and social functioning will be obtained at baseline, mid-treatment, end of treatment, and 6 month follow-up. We hypothesize that participation in the cognitive-behavioral therapy will lead to greater reductions in symptoms and improvements in social functioning.|
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