Overview

This trial is active, not recruiting.

Conditions brain and central nervous system tumors, cognitive/functional effects, long-term effects secondary to cancer therapy in children, ototoxicity
Treatments carboplatin, cisplatin, cyclophosphamide, methotrexate, vincristine sulfate, adjuvant therapy, cognitive assessment, magnetic resonance imaging, magnetic resonance spectroscopic imaging, quality-of-life assessment
Phase phase 3
Sponsor Children's Cancer and Leukaemia Group
Start date April 2008
End date March 2034
Trial size 50 participants
Trial identifier NCT00683319, CCLG-CNS-2007-09, CDR0000590666, EU-20835

Summary

RATIONALE: Gathering information about how young patients with ependymoma respond to standard combination chemotherapy and learning about the long-term effects of this treatment may help doctors plan better treatment.

PURPOSE: This phase III trial is observing young patients with ependymoma undergoing standard combination chemotherapy.

United States No locations recruiting
Other Countries No locations recruiting

Primary Outcomes

Measure
Overall survival
time frame:
Event-free survival
time frame:
Response to chemotherapy, if there is residual disease
time frame:
Requirement for radiotherapy (i.e., residual disease at the completion of chemotherapy, progressive disease during chemotherapy, or recurrent disease during or after completion chemotherapy)
time frame:
Late effects of treatment (i.e., ototoxicity and nephrotoxicity at the completion of chemotherapy and neurocognitive outcomes at 5, 7, 11, and 16 years of age)
time frame:

Eligibility Criteria

Male or female participants up to 2 years old.

DISEASE CHARACTERISTICS: - Histologically confirmed WHO grade 3 anaplastic (malignant) ependymoma or WHO grade 2 ependymoma, including the following variants: - Papillary - Cellular - Clear cell - Tanycytic - No myxopapillary ependymoma, subependymoma, or ependymoblastoma - Meets 1 of the following criteria: - Has undergone complete resection of the primary tumor (prior to starting chemotherapy) - Two or more surgical procedures to achieve complete resection allowed - Metastatic disease at diagnosis (with or without complete resection of the primary tumor) - Unable to undergo complete resection of the primary tumor (with or without metastatic disease) - Patients with measurable residual disease (primary or metastatic disease) are eligible provided they undergo treatment on clinical trial CCLG-CNS-2005-03 prior to entering this study - Has undergone surgical resection OR completed treatment on clinical trial CCLG-CNS-2005-03 within the past 3 weeks - Patients who are unable to tolerate chemotherapy or who do not receive treatment according to the CCLG guidelines for ependymoma due to parental preference or recommendation from the treating physician are eligible PATIENT CHARACTERISTICS: - Able to tolerate IV hydration - No active infection PRIOR CONCURRENT THERAPY: - See Disease Characteristics

Additional Information

Official title CCLG Observational Study of the Outcome of Ependymoma in Infants Diagnosed Before Their Third Birthday
Principal investigator Martin W. English, MD
Description OBJECTIVES: Primary - To determine the overall survival and event-free survival of all infants diagnosed with ependymoma before their third birthday. - To determine the overall survival and event-free survival of infants diagnosed with ependymoma before their third birthday when treated with standard chemotherapy comprising vincristine, carboplatin, high-dose methotrexate, cyclophosphamide, and cisplatin. Secondary - To investigate the reasons why the primary tumor was completely resected in patients who were able to undergo complete resection of the tumor. - To continue to investigate the biological characteristics of ependymoma. - To correlate functional imaging studies of ependymoma with biological characteristics of the tumor. - To provide a standard treatment regimen for patients with residual disease after optimal surgery who have already participated in a phase II study. - To prospectively document renal function, hearing, and neurocognitive late effects after completion of study treatment. OUTLINE: This is a multicenter study. Patients are stratified according to extent of prior surgical resection and presence of metastatic disease (complete resection of tumor vs metastatic disease at diagnosis vs no complete resection of tumor). Patients receive vincristine IV on days 1, 15, and 29, carboplatin IV over 1 hour on day 1, high-dose methotrexate* IV over 24 hours on day 15, cyclophosphamide IV over 1 hour on day 29, and cisplatin IV over 48 hours on days 43 and 44. Treatment repeats every 8 weeks for 7 courses in the absence of disease progression or unacceptable toxicity. Patients with residual disease after completion of treatment may receive other treatment at the discretion of the investigator. NOTE: *Patients initially treated on clinical trial CCLG-CNS-2005-03 who have no residual disease do not receive high-dose methotrexate in courses 5-7. Patients undergo observational assessments comprising physical and neurological examination; MRI/ MRS scanning of the head and spine; and audiology, renal, endocrine, neurocognitive, and quality of life evaluations periodically for at least 5 years after the completion of study treatment.
Trial information was received from ClinicalTrials.gov and was last updated in September 2013.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).