Overview

This trial is active, not recruiting.

Conditions adult giant cell glioblastoma, adult glioblastoma, adult gliosarcoma
Treatments cediranib maleate, diffusion tensor imaging, diffusion weighted imaging, dynamic contrast-enhanced magnetic resonance imaging, fludeoxyglucose f-18, intensity-modulated radiation therapy, laboratory biomarker analysis, perfusion magnetic resonance imaging, positron emission tomography, temozolomide
Phase phase 1/phase 2
Sponsor National Cancer Institute (NCI)
Start date April 2008
End date March 2017
Trial size 40 participants
Trial identifier NCT00662506, 8030, CDR0000593717, MGH-07-344, NCI-2009-00267, P30CA006516, PHS 398/2590, R01CA129371

Summary

This phase I/II trial is studying the side effects and best dose of cediranib to see how well it works when given together with temozolomide and radiation therapy in treating patients with newly diagnosed glioblastoma. Cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cediranib together with temozolomide and radiation therapy may kill more tumor cells.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
See Detailed Description
cediranib maleate AZD2171
Given PO
diffusion tensor imaging DTI
Undergo DTI
diffusion weighted imaging Diffusion Weighted MRI
Undergo T1 weighted DCE-MRI
dynamic contrast-enhanced magnetic resonance imaging DCE MRI
Undergo DCE-MRI
fludeoxyglucose f-18 18FDG
Undergo 18 FDG PET
intensity-modulated radiation therapy IMRT
Undergo IMRT
laboratory biomarker analysis
Correlative studies
perfusion magnetic resonance imaging magnetic resonance perfusion imaging
Undergo PWI
positron emission tomography Medical Imaging, Positron Emission Tomography
Undergo 18 F FDG-PET
temozolomide CCRG-81045
Given PO

Primary Outcomes

Measure
Progression-free survival (Phase II)
time frame: At day 218
Safety profile and optimal dose of cediranib during chemoradiotherapy (Phase I)
time frame: Up to 30 days after the last dose

Secondary Outcomes

Measure
Blood biomarkers (Phase II)
time frame: Up to 1 year
MRI parameters (Phase II)
time frame: Up to 48 weeks
Tumor biomarkers (Phase II)
time frame: At baseline

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Histologically confirmed glioblastoma - Newly diagnosed disease - Scheduled to receive standard post-surgical (i.e., biopsy or resection) temozolomide and radiotherapy - Must have residual, contrast-enhancing tumor (≥ 1 centimeter in ≥ 1 dimension) - Patients must be maintained on a stable corticosteroid regimen for 5 days prior to their baseline scan and for 5 days prior to their first vascular MRI; the dose of steroids should remain the same during the baseline vascular MRIs - Archival tumor tissue available for molecular analysis - No intratumoral hemorrhage or peritumoral hemorrhage by MRI - Karnofsky performance status 60-100% - Leukocytes ≥ 3,000/mcl - Absolute neutrophil count ≥ 1,500/mcL - Platelet count ≥ 100,000/mcL - Hemoglobin ≥ 8 g/dL - Total bilirubin normal - AST/ALT ≤ 2.5 times upper limit of normal - Creatinine normal OR creatinine clearance ≥ 60 mL/min - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - Proteinuria ≤ 1+ on two consecutive dipsticks ≥ 7 days apart - Mini-mental status examination score ≥ 15 - Must be able to tolerate MRI and must consent to participate in additional Vascular Imaging Procedures per protocol - CT scans cannot be substituted for MRI - Mean QTc ≤ 500 msec (with Bazett's correction) by electrocardiogram - No concurrent malignancy except curatively treated basal cell or squamous cell carcinoma skin cancer or carcinoma in situ of the cervix or breast - Patients with prior malignancies must be disease-free for ≥ 5 years - No history of familial long QT syndrome or other significant ECG abnormality - No history of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib - No uncontrolled intercurrent illness including, but not limited to, any of the following: - Hypertension (e.g., blood pressure > 140/90 mm Hg) - Ongoing or active infection - Symptomatic congestive heart failure - Unstable angina pectoris - Cardiac arrhythmia - Psychiatric illness/social situations that would preclude study compliance - No known coagulopathy that increases risk of bleeding - No history of clinically significant hemorrhages in the past - No New York Heart Association class III-IV heart disease - No condition requiring concurrent drugs or biologics with proarrhythmic potential - No other concurrent chemotherapy agents, investigational agents, or biologic therapy - No prior chemotherapy, radiotherapy, or any experimental therapy for this disease - No prior IV bevacizumab for any other medical condition - No prior carmustine implant (Gliadel Wafer) - No prior brachytherapy or radiosurgery for this disease - More than 30 days since prior and no other concurrent investigational agents or participation in an investigational therapeutic trial - At least 2 weeks since prior and no concurrent enzyme-inducing anti-epileptic drugs (EIAEDs) - Concurrent non-EIAEDs allowed - No concurrent CYP450-inducing anticonvulsants - No concurrent anticoagulants (e.g., dalteparin, warfarin, or low-molecular weight heparin) - If patients require warfarin or other anticoagulants (e.g., low-molecular weight heparin) while on study, then patient may continue treatment - No concurrent combination antiretroviral therapy for HIV-positive patients - No concurrent VEGF inhibitors - No concurrent pentamidine - No concurrent herbal or nontraditional medications

Additional Information

Official title A Phase Ib/II Study of AZD2171 in Combination With Daily Temozolomide and Radiation in Patients With Newly Diagnosed Glioblastoma Not Taking Enzyme-Inducing Anti-epileptic Drugs
Principal investigator Tracy Batchelor
Description PRIMARY OBJECTIVES: I. To determine the safety profile and optimal dose of AZD2171 (cediranib) (15mg or 20mg or 30mg) in combination with temozolomide and radiation in patients with newly diagnosed glioblastoma (Phase Ib) II. To determine median progression-free survival of patients with newly diagnosed glioblastoma treated with AZD2171 in combination with temozolomide and radiation (Phase II) SECONDARY OBJECTIVES: I. To determine the radiographic response proportion in newly diagnosed glioblastoma patients with measurable disease. (Phase II) II. To determine the median overall survival. (Phase II) III. To determine the "vascular normalization" window in newly diagnosed glioblastoma patients by the application of serial, non-invasive, MRI parameters. (Phase II) IV. To measure the glucose metabolism changes in a subset of newly diagnosed glioblastoma patients by performing FDG PET studies. (Phase II) V. Measurement of circulating endothelial and progenitor cells and plasma levels of VEGF-A; VEGF-B; VEGF-C; VEGF-D; sVEGFR1, sVEGFR2, bFGF, PlGF, PDGF-AA; PDGF-AB; PDGF-BB; SDF1α; tumstatin; thrombospondin-1; interleukin-8; collagen IV sICAM1, sVCAM1 as markers for response to AZD2171 in newly diagnosed glioblastoma patients. (Phase II) VI. Correlation of treatment outcomes with pre-AZD2171 tumor specimens with respect to cell proliferation, apoptosis, microvascular density (MVD), basement membrane and pericyte coverage, angiopoietin-1 and -2 expression to determine whether these immunohistochemical analyses can be predictive of the response to AZD2171. (Phase II) OUTLINE: This is a phase I, dose-escalation study of cediranib followed by a phase II study. Patients begin study treatment within 21-42 days after craniotomy or 14-21 days after stereotactic biopsy. PHASE Ib: CHEMORADIOTHERAPY: Patients receive cediranib orally (PO) once daily and oral temozolomide once daily for 6 weeks. Within 2-6 hours of dosing, patients undergo concurrent intensity-modulated radiotherapy (IMRT) once daily, 5 days a week for 6 weeks. Cediranib monotherapy: Patients receive cediranib PO once daily for 4 weeks (weeks 7-10). Cediranib and temozolomide monthly therapy: Patients receive cediranib PO once daily for 24 weeks (weeks 11-34) and temozolomide once daily, 5 days a week in weeks 11, 15, 19, 23, 27, and 31. Cediranib monotherapy: Patients receive a fixed-dose of cediranib once daily for 24 weeks (weeks 35-58). PHASE II: CHEMORADIOTHERAPY: Patients receive cediranib PO at the recommended phase II dose determined in phase Ib, temozolomide PO, and undergo concurrent IMRT as in phase Ib (weeks 1-6). Cediranib monotherapy: Patients receive cediranib PO (at the recommended phase II dose determined in phase Ib) once daily for 4 weeks (weeks 7-10). Cediranib and temozolomide monthly therapy: Patients receive cediranib PO (at the recommended phase II dose determined in phase Ib) once daily for 24 weeks (weeks 11-34) and temozolomide once daily, 5 days a week in weeks 11, 15, 19, 23, 27, and 31. Cediranib monotherapy: Patients receive a fixed-dose of cediranib once daily for 24 weeks (weeks 35-58). Patients undergo blood and urine sample collection at baseline and periodically during study. Blood samples are measured for tumstatin, as well as other well established biomarkers, including VEGF-A, -D, sVEGFR1, sVEGFR2, sICAM1, sVCAM1, PlGF, PDGF-AA, PDGF-AB, PDGF-BB, thrombospondin-1, and IL-8 by electrochemiluminescence detection. Circulating endothelial cell (CEC) assays are evaluated to assess the kinetics of CECs and progenitor cells prior to and during antiangiogenic therapy with cediranib and chemoradiotherapy. Urine samples are collected for proteomic analyses to evaluate serial change of growth factors such as VEGF and PlGF and of matrix metalloproteinases in response to treatment with cediranib. Archival tumor tissue is collected for analysis of tumor microvascular density, basement membrane and pericyte coverage, angiopoietin-1 and -2 expression, tumor cell proliferation, and apoptosis by immunostaining methods and immunoenzyme techniques. Patients also undergo dynamic contrast enhanced (DCE)-MRI and T2-weighted or perfusion-weighted MRI at baseline and periodically during study to monitor antiangiogenic effect on tumor vasculature through parameters reflecting both tumor perfusion and permeability; and diffusion tensor imaging to measure degree of water diffusion and fractional anisotropy. A subset of patients undergo fludeoxyglucose F 18 positron emission tomography (FDG-PET) periodically to monitor antiangiogenic effects on glucose utilization. After completion of study treatment, patients are followed periodically for 1 year.
Trial information was received from ClinicalTrials.gov and was last updated in November 2016.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).