This trial is active, not recruiting.

Condition pain
Treatment lidocaine
Sponsor University of Alabama at Birmingham
Collaborator American Society of Regional Anesthesia
Start date December 2008
End date June 2016
Trial size 10 participants
Trial identifier NCT00659633, F061204014


The purpose of this study is to study if lidocaine, given intravenously, reduces pain.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
(Active Comparator)
Intravenous lidocaine for neuropathic pain
lidocaine Lidoderm
intravenous, effect site concentration: 2mcg/ml, 15-20 min infusion, once

Primary Outcomes

Pain intensity
time frame: before, during, and after intravenous lidocaine

Eligibility Criteria

Male or female participants at least 19 years old.

Inclusion Criteria: - Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi Exclusion Criteria: - History of Substance abuse - Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis. - Coronary Artery Disease (CAD): unstable - Congestive Heart Failure (CHF): unstable - Heart Arrhythmia: symptomatic - Chronic Obstructive Pulmonary Disease (COPD) - Lidocaine Allergy - Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation. - Presence of Contraindications for MRI - Presence of electronically, magnetically, and mechanically activated implants - Electronically, magnetically, and mechanically activated implants - Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators - Cardiac pacemakers - Metallic splinters in the eye - Ferromagnetic haemostatic clips in the central nervous system (CNS) - Claustrophobia - Pregnancy

Additional Information

Official title The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)
Principal investigator Michael Froelich, MD, MS
Description Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.
Trial information was received from ClinicalTrials.gov and was last updated in August 2015.
Information provided to ClinicalTrials.gov by University of Alabama at Birmingham.