A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients
This trial is active, not recruiting.
|Treatments||multivitamin (mv), multivitamin + vitamin b12 + vitamin b6|
|Sponsor||New Mexico Cancer Care Alliance|
|Start date||July 2006|
|End date||June 2013|
|Trial size||450 participants|
|Trial identifier||NCT00659269, INST 0553C, NCI-2012-00946|
Many types of chemotherapy may cause nerve damage as a side effect. This neurotoxicity can manifest as peripheral sensory neuropathy (characterized by numbness, tingling, or pain). The goal of this study is to determine the efficacy of the combination of vitamin B6 and B12 in preventing chemotherapy induced neuropathy.
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
|Albuquerque, NM||Cancer Center at Presbyterian Hospital||no longer recruiting|
|Albuquerque, NM||Hematology Oncology Associates||no longer recruiting|
|Albuquerque, NM||University of New Mexico Cancer Center||no longer recruiting|
|Albuquerque, NM||University of New Mexico Cancer Center @ Lovelace Medical Center||no longer recruiting|
|Santa Fe, NM||New Mexico Cancer Care Associates||no longer recruiting|
|Endpoint classification||efficacy study|
|Intervention model||factorial assignment|
Improvement of neuropathy scores from baseline to the completion of 2 cycles will be analyzed.The same measurement after 4 cycles also will be analyzed & will be reported.
time frame: 4 weeks
Male or female participants at least 18 years old.
Inclusion Criteria: 1. All patients, 18 years of age or older, with a cancer treated with any of the following drugs are eligible: - Taxanes, vinca alkaloid analogs, heavy metals. - Each patient will be allocated to the following 3 groups: - Group 1 (Heavy metals): Patients treated with cisplatin (>25 mg/m2/week dose intensity) or oxaliplatin - Group 2 (Taxane): Patients treated with paclitaxel, docetaxel or abraxane - Group 3 (Vinca alkaloids): Patients treated with vincristine and vinorelbine. 2. Patients must have a life expectancy of at least 24 weeks. 3. Patients must have a Zubrod performance status of 0-2. 4. Patients must sign an informed consent. 5. Patients may have a grade 0 (chemotherapy naive) or 1 neuropathy (history of prior chemotherapy) prior to entry. Exclusion Criteria: 1. Patients with symptomatic brain metastases are excluded from this study. 2. Pregnant women or nursing mothers are not eligible for this trial. Patients of child bearing potential must use adequate contraception. 3. Patients may receive no other concurrent complementary medicines during this study. 4. Patients with neuropathy induced diabetes are not eligible for this study 5. Patients with severe medical problems such as uncontrolled diabetes mellitus or cardiovascular disease or active infections are not eligible for this trial.
|Official title||A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients.|
|Principal investigator||Zoneddy Dayao, MD|
|Description||Neuropathy can be a significant side effect of chemotherapy using platinum compounds, taxanes, and vinca alkaloids. There is clinical and preclinical data that vitamin B6 and B12 may alleviate neuropathy in experimentally induced neuropathy in animal models, or clinical neuropathy such as diabetic neuropathy. This is a randomized phase III study of the use of multivitamins with or without vitamin B6 and B12 to prevent or relieve neuropathic toxicity from chemotherapy in patients receiving chemotherapy. Patients will be stratified by type of chemotherapy agent (3 groups), presence or absence of neuropathy at baseline, and randomized to receive placebo or vitamin B6/B12 supplementation.|
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