Overview

This trial is active, not recruiting.

Condition turner syndrome
Sponsor University of Aarhus
Start date November 1994
End date October 1996
Trial size 54 participants
Trial identifier NCT00625001, 1994/2424

Summary

Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.

The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.

Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers.

Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Women with Turner syndrome
Healthy control women

Primary Outcomes

Measure
Bone Mineral Density in columna lumbalis, collum femoris and distal ulnae Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.
time frame: Evey 5 years

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: - Turner syndrome verified by karyotyping Exclusion Criteria: - untreated hypothyroidism or hyperthyroidism - present or past malignant diseases - clinical liver disease - treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)

Additional Information

Official title Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
Trial information was received from ClinicalTrials.gov and was last updated in February 2008.
Information provided to ClinicalTrials.gov by University of Aarhus.